Ethyl (2Z)-chloro(hydroxyimino)acetate(CAS: 14337-43-0)

Ethyl (2Z)-chloro(hydroxyimino)acetate (CAS: 14337-43-0) is a white crystalline solid with a molecular weight of approximately 179.57 g/mol. It has a solubility of about 1.4 g/L in water. This compound is reactive and can undergo nucleophilic substitution and addition reactions. It is sparingly soluble in water but readily soluble in organic solvents like ethanol and acetone.

Ethyl (2Z)-chloro(hydroxyimino)acetate (CAS: 14337-43-0) is typically synthesized through the reaction of ethyl acetoacetate with hydroxylamine hydrochloride in the presence of a Lewis acid catalyst, such as boron trifluoride etherate. The reaction proceeds via a chlorocarbonyl intermediate, yielding a high yield of the desired product with good selectivity.

Ethyl (2Z)-chloro(hydroxyimino)acetate (CAS: 14337-43-0) is used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also has applications in the polymer industry, where it serves as a crosslinking agent. Additionally, it is employed in the development of sensors and as a reagent in analytical chemistry.

Handling Ethyl (2Z)-chloro(hydroxyimino)acetate (CAS: 14337-43-0) requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a fume hood due to its reactivity. Spills should be immediately cleaned up using appropriate absorbents, and the area should be well ventilated. Safety data sheets (SDS) should be consulted for detailed safety information and emergency procedures.