Vinblastine sulfate

Basic Information

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CAS Number

143-67-9

Molecular Formula

C46H58N4O9.H2O4S

Molecular Weight

909.07 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

267 ºC

Density

1.3700

Water Solubility

>=1 g/100 mL at 24.5 ºC

Solubility

H2O: 10 mg/mL

Specific Rotation

-21.7 º (c=2, CH3OH 21 ºC)

SMILES

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CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

InChI

InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1

InChIKey

KDQAABAKXDWYSZ-PNYVAJAMSA-N

LogP

3.3381000000000034

Topological Polar Surface Area

228.69999999999996 Å²

Hydrogen Bond Donor/Acceptor

5 / 17

Complexity

1780

Safety Information

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GHS Hazard Pictograms

H302

H315

H318

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1(a) Class 6.1(a)

Storage Conditions

-20℃

Toxicity

LD50 i.v. in mice: 9.5 mg/kg (Lu, Meistrich)

Synonyms & References

English

NCGC00344583-01
vinblastinesulfate
Vinblastine (sulfate)
VINBLASTINE SULFATE [USAN]
NS00076398
MLS002207069
DSSTox_GSID_47853
N00W22YO2B
Vinblastine sulfate salt, powder, >=96% (HPLC)
Vinblastine sulfate, European Pharmacopoeia (EP) Reference Standard
Methyl (3aR,4R,5S,5aR,10bR,13aR)-4-acetoxy-3a-ethyl-9-((5S,7R,9S)-5-ethyl-5-hydroxy-9-methoxycarbonyl-1,4,5,6,7,8,9,10-octahydro-3,7-methano-3-azacycloundecino(5,4-b)indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino(8,1-cd)carbazole-5-carboxylate monosulfate
CAS-18556-44-0
HY-13780
MLS000069550
SR-01000000155-7
SR-01000000155
SMR000058844
MLS002153253
EINECS 205-606-0
Vinblastine sulphate
NCGC00095285-01
CCRIS 2584
Belvan, VLB
Rozevin sulfate
VINBLASTINE SULFATE (IARC)
Velsar
DTXCID7027831
VINBLASTINE SULFATE [USP-RS]
29060LE
VINBLASTINE SULFATE [EP MONOGRAPH]
MLS000863275

MDL Number

MFCD00082457

Customs Code

2942000000

FAQ

What is Vinblastine sulfate (CAS: 143-67-9)?

Vinblastine sulfate is a chemotherapy drug used to treat various cancers. It has the chemical formula C20H24N4O12S2 and is a derivative of the alkaloid vinblastine. This compound is known for its ability to inhibit cell division by interfering with microtubule formation, making it an important antimitotic agent in oncology.

What are the main uses of Vinblastine sulfate (CAS: 143-67-9)?

Vinblastine sulfate is primarily used in cancer treatment, particularly for Hodgkin’s lymphoma, testicular cancer, and leukemia. It is also employed in research for studying cell division mechanisms and in pharmaceutical formulations as an active ingredient. The compound’s antitumor properties make it a key component in chemotherapy regimens.

Is Vinblastine sulfate (CAS: 143-67-9) safe?

Vinblastine sulfate is generally safe when used under medical supervision, but it can have side effects such as bone marrow suppression and neuropathy. Proper handling, including the use of personal protective equipment, is essential to minimize risks. Safety standards ensure its controlled use in healthcare settings to protect both patients and handlers.

How should Vinblastine sulfate (CAS: 143-67-9) be stored?

Vinblastine sulfate should be stored in a cool, dry place away from light. It is typically kept in airtight containers at a temperature range of 20-25°C. Maintaining proper humidity levels and avoiding exposure to moisture is crucial for preserving its stability and potency over time.