5,5'-Bis(trifluoromethyl)-2,2'-bipyridine

Basic Information

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CAS Number

142946-80-3

Molecular Formula

C12H6F6N2

Molecular Weight

292.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

129.0 to 133.0 deg-C

Boiling Point

275.3±35.0 ºC (760 Torr),

Density

1.403±0.06 g/cm3 (20 ºC 760 Torr),

Flash Point

120.3±25.9 ºC,

SMILES

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FC(C1=CN=C(C2=NC=C(C(F)(F)F)C=C2)C=C1)(F)F

InChI

InChI=1S/C12H6F6N2/c13-11(14,15)7-1-3-9(19-5-7)10-4-2-8(6-20-10)12(16,17)18/h1-6H

InChIKey

ZHMXQYAUGQASQM-UHFFFAOYSA-N

LogP

4.181200000000001

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

295

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

5-(trifluoromethyl)-2-[5-(trifluoromethyl)pyridin-2-yl]pyridine
5,5'-Bis(trifluoromethyl)-2,2'-bipyridyl
5,5'-Bis(trifluoromethyl)-2,2'-bipyridine
5,5'-Di(trifluoromethyl)-2,2'-bypyridine
2,2'-Bipyridine, 5,5'-bis(trifluoromethyl)-
5,5'-Di(trifluoromethyl)-2,2'-bipyridyl
BPCF21
ZHMXQYAUGQASQM-UHFFFAOYSA-N
5,5'-ditrifluoromethyl-2,2'-bipyridine
AK200534
5,5'-Di(trifluoromethyl)-2,2'-bipyridine

MDL Number

MFCD24449717

FAQ

What are the physical and chemical properties of 5,5'-Bis(trifluoromethyl)-2,2'-bipyridine (CAS: 142946-80-3)?

5,5'-Bis(trifluoromethyl)-2,2'-bipyridine is a crystalline solid with a high molecular weight. It is moderately soluble in common organic solvents like DMSO and DMF. The compound is known for its high stability and low reactivity under normal conditions, making it suitable for a variety of applications in research and industry.

How is 5,5'-Bis(trifluoromethyl)-2,2'-bipyridine (CAS: 142946-80-3) typically synthesized?

5,5'-Bis(trifluoromethyl)-2,2'-bipyridine is synthesized by the coupling of 2,2'-bipyridine with trifluoromethylating agents such as trifluoromethyl chlorides in the presence of a suitable catalyst. The reaction proceeds with good yield and selectivity, making it a reliable method for large-scale production.

What industries use 5,5'-Bis(trifluoromethyl)-2,2'-bipyridine (CAS: 142946-80-3)?

5,5'-Bis(trifluoromethyl)-2,2'-bipyridine finds applications in pharmaceuticals, where it is used as an intermediate in the synthesis of new drugs. It is also utilized in the development of sensors, semiconductors, and polymers due to its unique electronic properties.

What precautions should be taken when handling 5,5'-Bis(trifluoromethyl)-2,2'-bipyridine (CAS: 142946-80-3)?

When handling 5,5'-Bis(trifluoromethyl)-2,2'-bipyridine, it is recommended to use personal protective equipment (PPE) such as gloves and goggles. This compound should be stored in a well-ventilated area and handled in a fume hood to minimize exposure. In case of spill, follow the safety data sheet (SDS) guidelines for cleanup and disposal.