2-Chloro-4,6-dimethylnicotinonitrile

Basic Information

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CAS Number

14237-71-9

Molecular Formula

C8H7ClN2

Molecular Weight

166.61 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

97.0 to 101.0 deg-C

Boiling Point

305.3 °C at 760 mmHg

Density

1.22

Flash Point

138.5 °C

Refractive Index

1.546

SMILES

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CC1=CC(=NC(=C1C#N)Cl)C

InChI

InChI=1S/C8H7ClN2/c1-5-3-6(2)11-8(9)7(5)4-10/h3H,1-2H3

InChIKey

RETJKTAVEQPNMH-UHFFFAOYSA-N

LogP

2.22348

Complexity

184

Safety Information

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Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

EU-0030011
HMS1646O06
BB 0219256
3-cyano-2-chloro-4,6-dimethylpyridine
J-508716
HMS2576C13
Z57683668
2-Chloro-3-cyano-4,6-dimethylpyridine
2-chloro-4,6-dimethyinicotinonitrile
4,6-dimethyl-2-chloro-nicotinonitrile
AC-907/25014202
DTXSID50278939
MFCD00051676
SCHEMBL318407
SY022505
NSC-10732
EN300-18260
MLS000417104
AM86591
SR-01000534009
F1371-0162
2-Chloro-4,6-dimethylnicotinonitrile #
NSC10732
2-chloro-4,6-dimethyl-3-pyridinecarbonitrile
2-Chloro-4,6-dimethylnicotinonitrile
CHEMBL1519270
SB52296
3-Pyridinecarbonitrile, 2-chloro-4,6-dimethyl-
SMR000264363
2-chloro-4,6-dimethyl-pyridine-3-carbonitrile;2-Chloro-4,6-dimethylnicotinonitrile
2-Chloro-4,6-dimethylpyridine-3-carbonitrile

MDL Number

MFCD00051676

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Chloro-4,6-dimethylnicotinonitrile (CAS: 14237-71-9)?

2-Chloro-4,6-dimethylnicotinonitrile (CAS: 14237-71-9) is a crystalline solid with a molecular weight of 218.03 g/mol. It has a low solubility in water but is more soluble in organic solvents. The compound is not highly reactive but can undergo nucleophilic substitution reactions. It has a melting point of 122-124°C and is stable under normal conditions.

How is 2-Chloro-4,6-dimethylnicotinonitrile (CAS: 14237-71-9) typically synthesized?

2-Chloro-4,6-dimethylnicotinonitrile (CAS: 14237-71-9) can be synthesized by reacting 2,6-dimethylpyridine with chloroacetonitrile and a base. Commonly used bases include sodium hydride or potassium tert-butoxide. The reaction is typically carried out in anhydrous conditions to enhance selectivity and yield.

What industries use 2-Chloro-4,6-dimethylnicotinonitrile (CAS: 14237-71-9)?

2-Chloro-4,6-dimethylnicotinonitrile (CAS: 14237-71-9) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also utilized in the polymer industry for modifying the properties of various polymers. Additionally, it has applications in the production of sensors and semiconductors.

What precautions should be taken when handling 2-Chloro-4,6-dimethylnicotinonitrile (CAS: 14237-71-9)?

When handling 2-Chloro-4,6-dimethylnicotinonitrile (CAS: 14237-71-9), it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The substance should be stored in a well-ventilated area and kept away from strong oxidizers. In case of a spill, it should be cleaned up using appropriate safety protocols, and the area should be properly ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.