2-Chloro-4,6-dimethylnicotinonitrile(CAS: 14237-71-9)

2-Chloro-4,6-dimethylnicotinonitrile (CAS: 14237-71-9) is a crystalline solid with a molecular weight of 218.03 g/mol. It has a low solubility in water but is more soluble in organic solvents. The compound is not highly reactive but can undergo nucleophilic substitution reactions. It has a melting point of 122-124°C and is stable under normal conditions.

2-Chloro-4,6-dimethylnicotinonitrile (CAS: 14237-71-9) can be synthesized by reacting 2,6-dimethylpyridine with chloroacetonitrile and a base. Commonly used bases include sodium hydride or potassium tert-butoxide. The reaction is typically carried out in anhydrous conditions to enhance selectivity and yield.

2-Chloro-4,6-dimethylnicotinonitrile (CAS: 14237-71-9) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also utilized in the polymer industry for modifying the properties of various polymers. Additionally, it has applications in the production of sensors and semiconductors.

When handling 2-Chloro-4,6-dimethylnicotinonitrile (CAS: 14237-71-9), it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The substance should be stored in a well-ventilated area and kept away from strong oxidizers. In case of a spill, it should be cleaned up using appropriate safety protocols, and the area should be properly ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.