Ethyl 3-aminoisonicotinate

Basic Information

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CAS Number

14208-83-4

Molecular Formula

C8H10N2O2

Molecular Weight

166.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

65.0 to 69.0 deg-C

Boiling Point

303.9℃ at 760 mmHg

Density

1.192

Flash Point

137.6℃

Refractive Index

1.559

SMILES

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CCOC(=O)C1=C(C=NC=C1)N

InChI

InChI=1S/C8H10N2O2/c1-2-12-8(11)6-3-4-10-5-7(6)9/h3-5H,2,9H2,1H3

InChIKey

BIFLTHWDFNLOTD-UHFFFAOYSA-N

LogP

0.8405

Topological Polar Surface Area

65.21 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

161

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

3-Aminoisonicotinic acid ethyl ester
3-Aminopyridine-4-carboxylic acid ethyl ester
ethyl 3-aminoisonicotinate
4-Pyridinecarboxylic acid, 3-amino-, ethyl ester
CS-D0762
3-Amino-4-pyridinecarboxylic acid ethyl ester
3-Amino-isonicotinic acid ethyl ester
SCHEMBL1841640
MFCD03788270
DTXSID60371309
AMY13364
E1137
3-Amino-isonicotinic acid ethyl ester;Ethyl 3-Aminoisonicotinate
AB15955
AC-976
SY007491
3-Amino-4-(ethoxycarbonyl)pyridine
FS-2558
14208-83-4
FT-0648891
Ethyl3-amino-4-pyridinecarboxylate
AKOS006229784
BIFLTHWDFNLOTD-UHFFFAOYSA-N
Ethyl 3-aminopyridine-4-carboxylate
W-205566
EN300-116625
AC-3597
Z1201622438
Ethyl 3-amino-4-pyridinecarboxylate
ETHYL 3-AMINOPYRIDINE-4-CARBOXYLATE
3-AMINOPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER

MDL Number

MFCD03788270

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Ethyl 3-aminoisonicotinate (CAS: 14208-83-4)?

Ethyl 3-aminoisonicotinate (CAS: 14208-83-4) is a crystalline compound with a molecular weight of approximately 194.25 g/mol. It is sparingly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is relatively stable but can undergo hydrolysis in the presence of moisture. It may react with bases to form salts.

How is Ethyl 3-aminoisonicotinate (CAS: 14208-83-4) typically synthesized?

Ethyl 3-aminoisonicotinate (CAS: 14208-83-4) is synthesized by the amidation of nicotinic acid with ethylamine. Commonly, this reaction is carried out in the presence of a base like sodium hydroxide to enhance the nucleophilicity of ethylamine. The reaction is typically performed in a solvent like ethanol, with good yield and selectivity.

What industries use Ethyl 3-aminoisonicotinate (CAS: 14208-83-4)?

Ethyl 3-aminoisonicotinate (CAS: 14208-83-4) is primarily used in the pharmaceutical industry for the synthesis of certain medications. It is also used in the production of some organic semiconductors and as a precursor in the development of advanced materials for sensors and electronics.

What precautions should be taken when handling Ethyl 3-aminoisonicotinate (CAS: 14208-83-4)?

Proper handling of Ethyl 3-aminoisonicotinate (CAS: 14208-83-4) requires the use of appropriate personal protective equipment (PPE), such as gloves and safety goggles. The compound should be stored in a cool, dry place, away from strong acids and bases. In case of a spill, it should be handled with care, using appropriate cleanup procedures as outlined in the Safety Data Sheet (SDS).