N-(2-hydroxyethyl)acetamide

Basic Information

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CAS Number

142-26-7

Molecular Formula

C4H9NO2

Molecular Weight

103.12 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

15.8 °C

Boiling Point

151-155 °C/5 mmHg

Water Solubility

Soluble in water, 1e+006 mg/L @ 25°C (est), soluble in alcohol and ether.

Refractive Index

n20/D 1.472(lit.)

SMILES

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CC(=O)NCCO

InChI

InChI=1S/C4H9NO2/c1-4(7)5-2-3-6/h6H,2-3H2,1H3,(H,5,7)

InChIKey

PVCJKHHOXFKFRP-UHFFFAOYSA-N

LogP

-0.8852

Topological Polar Surface Area

49.33 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

62.7

Safety Information

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GHS Hazard Pictograms

H315

H318

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Sensitive to moisture

Synonyms & References

English

N-(2-Hydroxyethyl)acetamide
2-(Acetamido)ethanol~N-(2-Hydroxyethyl)acetamide
N-Acetylethanolamine
2-Acetamidoethanol
N-(2-Hydroxyethyl)acetamid
N-2-Hydroxyethylacetamide
N-ACETYLETHANOLAMINE ---OILY LIQUID---
2-Acetylaminoethanol
Acetamide,N-(2-hydroxyethyl)
Acetylcolamine
ACETYLETHANOLAMINE
N-(2-hydroxyethyl)-acetamide
N-acetyl aminoethanol
N-Acetyl-2-aminoethanol
N-acetyl-N-(2-hydroxyethyl)amine
N-Ethanolacetamide
Amidex AME
Hetamide MA
Acetamide MEA
Foamid AME-70
Foamid AME-75
Lipamide MEAA
Upamide ACMEA
Foamid AME-100
Carsamide AMEA
Acetamide, N-(2-hydroxyethyl)-
Hydroxyethyl acetamide
N-Acetyl ethanolamine
beta-Hydroxyethylacetamide
N-beta-Hydroxyethylacetamide
.beta.-Hydroxyethylacetamide

MDL Number

MFCD00002836

Customs Code

2924199090

FAQ

What are the physical and chemical properties of N-(2-hydroxyethyl)acetamide (CAS: 142-26-7)?

N-(2-hydroxyethyl)acetamide (CAS: 142-26-7) is a white, crystalline solid with a molecular weight of approximately 112.13 g/mol. It is slightly soluble in water and has a pKa of around 4.5. The compound is weakly basic and exhibits good solubility in polar solvents. It is relatively stable under normal conditions but may hydrolyze in strongly acidic or basic media.

How is N-(2-hydroxyethyl)acetamide (CAS: 142-26-7) typically synthesized?

N-(2-hydroxyethyl)acetamide is typically synthesized via the reaction of acetic anhydride with ethylene glycol. The process involves the condensation of the carboxylic acid group of acetic anhydride with the hydroxyl group of ethylene glycol in the presence of an acid catalyst such as sulfuric acid. The product is then purified by recrystallization from water or methanol.

What industries use N-(2-hydroxyethyl)acetamide (CAS: 142-26-7)?

N-(2-hydroxyethyl)acetamide (CAS: 142-26-7) is used in various industries, including pharmaceuticals, where it serves as a precursor in drug synthesis. It is also utilized in the production of polymers, particularly in the modification of polyester resins. Additionally, it finds applications in the manufacturing of sensors and semiconductors as a component of surface treatment solutions.

What precautions should be taken when handling N-(2-hydroxyethyl)acetamide (CAS: 142-26-7)?

When handling N-(2-hydroxyethyl)acetamide (CAS: 142-26-7), it is essential to use appropriate personal protective equipment (PPE), including gloves and safety goggles. The substance should be stored in a cool, dry place away from heat sources and protected from moisture. Spills should be handled with caution using appropriate absorbent materials and disposing of the waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.