N-(2-hydroxyethyl)acetamide(CAS: 142-26-7)

N-(2-hydroxyethyl)acetamide (CAS: 142-26-7) is a white, crystalline solid with a molecular weight of approximately 112.13 g/mol. It is slightly soluble in water and has a pKa of around 4.5. The compound is weakly basic and exhibits good solubility in polar solvents. It is relatively stable under normal conditions but may hydrolyze in strongly acidic or basic media.

N-(2-hydroxyethyl)acetamide is typically synthesized via the reaction of acetic anhydride with ethylene glycol. The process involves the condensation of the carboxylic acid group of acetic anhydride with the hydroxyl group of ethylene glycol in the presence of an acid catalyst such as sulfuric acid. The product is then purified by recrystallization from water or methanol.

N-(2-hydroxyethyl)acetamide (CAS: 142-26-7) is used in various industries, including pharmaceuticals, where it serves as a precursor in drug synthesis. It is also utilized in the production of polymers, particularly in the modification of polyester resins. Additionally, it finds applications in the manufacturing of sensors and semiconductors as a component of surface treatment solutions.

When handling N-(2-hydroxyethyl)acetamide (CAS: 142-26-7), it is essential to use appropriate personal protective equipment (PPE), including gloves and safety goggles. The substance should be stored in a cool, dry place away from heat sources and protected from moisture. Spills should be handled with caution using appropriate absorbent materials and disposing of the waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.