Mometasone Furoate Monohydrate

Basic Information

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CAS Number

141646-00-6

Molecular Formula

C27H32Cl2O7

Molecular Weight

539.45 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CCl)OC(=O)C5=CC=CO5)C)O)Cl)C.O

InChI

InChI=1S/C27H30Cl2O6.H2O/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20;/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3;1H2/t15-,18+,19+,21+,24+,25+,26+,27+;/m1./s1

InChIKey

AQCCVUHZMIMSIB-HRVPQZBTSA-N

LogP

4.044500000000006

Topological Polar Surface Area

125.31000000000002 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

1020

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Mometasone Furoate Monohydrate
Nasonex
Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-((2-furanylcarbonyl)oxy)-11-hydroxy-16-methyl-, monohydrate, (11beta,16alpha)-
Mometasonefuroatehydrate
[(9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate,hydrate
Mometasone furoate hydrate
AK162361
[(8S,9R,10S,13S,14S,17R)-9-Chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,1
Mometasone Furoate Hydrate
PREGNA-1,4-DIENE-3,20-DIONE, 9,21-DICHLORO-17-((2-FURANYLCARBONYL)OXY)-11-HYDROXY-16-METHYL-, (11beta,16alpha)-MONOHYDRATE
AKOS025402565
Monohydrate, Mometasone Furoate
C72635
D03325
9,21-Dichloro-11beta,17alpha-dihydroxy-16a-methyl-1,4-pregnadiene-3,20-dione 17-(2-furoate) monohydrate
[(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate;hydrate
MOMETASONE FUROATE MONOHYDRATE [EP MONOGRAPH]
PREGNA-1,4-DIENE-3,20-DIONE, 9,21-DICHLORO-17-((2-FURANYLCARBONYL)OXY)-11-HYDROXY-16-METHYL-, HYDRATE (1:1), (11beta,16alpha)-
Mometasone furoate hydrate (JAN)
9alpha,21-Dichloro-11beta,17alpha-dihydroxy-16alpha-methyl-3,20-dioxodipregna-1,4-dien-17-yl furan-2-carboxylate monohydrate
PREGNA-1,4-DIENE-3,20-DIONE, 9,21-DICHLORO-17-((2-FURANYLCARBONYL)OXY)-11-HYDROXY-16-METHYL-, HYDRATE (1:1), (11.BETA.,16.ALPHA.)-
RYALTRIS COMPONENT MOMETASONE FUROATE MONOHYDRATE
MOMETASONE FUROATE MONOHYDRATE [GREEN BOOK]
MTW0WEG809
PREGNA-1,4-DIENE-3,20-DIONE, 9,21-DICHLORO-17-((2-FURANYLCARBONYL)OXY)-11-HYDROXY-16-METHYL-, (11.BETA.,16.ALPHA.)-MONOHYDRATE
MOMETASONE FUROATE (AS MONOHYDRATE)
MOMETASONE FUROATE MONOHYDRATE COMPONENT OF RYALTRIS
MOMETASONE FUROATE MONOHYDRATE [MI]
UNII-MTW0WEG809
MOMETASONE FUROATE MONOHYDRATE [VANDF]
MOMETASONE FUROATE MONOHYDRATE [WHO-DD]

MDL Number

MFCD00866003

FAQ

What are the physical and chemical properties of Mometasone Furoate Monohydrate (CAS: 141646-00-6)?

Mometasone furoate monohydrate is a white to off-white crystalline powder. It has a molecular weight of approximately 446.53 g/mol. The compound is sparingly soluble in water and is slightly soluble in ethanol. Chemically, it is highly reactive with bases and sensitive to light and moisture, which requires careful storage and handling.

How is Mometasone Furoate Monohydrate (CAS: 141646-00-6) typically synthesized?

Mometasone furoate monohydrate is synthesized by the furoylation of mometasone acetate. This involves reacting mometasone acetate with furoic anhydride in the presence of a catalyst such as p-toluenesulfonic acid. The yield is typically around 80%, and the process requires careful control of temperature and reaction time to ensure selectivity and purity.

What industries use Mometasone Furoate Monohydrate (CAS: 141646-00-6)?

Mometasone furoate monohydrate is primarily used in the pharmaceutical industry for the treatment of inflammatory and allergic skin conditions. It is also used in research for its anti-inflammatory properties and in certain polymers and sensors for its unique chemical behavior.

What precautions should be taken when handling Mometasone Furoate Monohydrate (CAS: 141646-00-6)?

When handling mometasone furoate monohydrate, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate procedures as outlined in the safety data sheet (SDS). Storage should be in a cool, dry place, away from direct sunlight and heat sources.