Mometasone Furoate Monohydrate(CAS: 141646-00-6)

Mometasone furoate monohydrate is a white to off-white crystalline powder. It has a molecular weight of approximately 446.53 g/mol. The compound is sparingly soluble in water and is slightly soluble in ethanol. Chemically, it is highly reactive with bases and sensitive to light and moisture, which requires careful storage and handling.

Mometasone furoate monohydrate is synthesized by the furoylation of mometasone acetate. This involves reacting mometasone acetate with furoic anhydride in the presence of a catalyst such as p-toluenesulfonic acid. The yield is typically around 80%, and the process requires careful control of temperature and reaction time to ensure selectivity and purity.

Mometasone furoate monohydrate is primarily used in the pharmaceutical industry for the treatment of inflammatory and allergic skin conditions. It is also used in research for its anti-inflammatory properties and in certain polymers and sensors for its unique chemical behavior.

When handling mometasone furoate monohydrate, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate procedures as outlined in the safety data sheet (SDS). Storage should be in a cool, dry place, away from direct sunlight and heat sources.