(2R)-1-(6-Amino-9H-purin-9-yl)-2-propanol

Basic Information

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CAS Number

14047-28-0

Molecular Formula

C8H11N5O

Molecular Weight

193.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

198.0 to 202.0 deg-C

Boiling Point

457.7°C at 760 mmHg

Flash Point

230.6°C

Refractive Index

1.752

SMILES

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CC(CN1C=NC2=C(N=CN=C21)N)O

InChI

InChI=1S/C8H11N5O/c1-5(14)2-13-4-12-6-7(9)10-3-11-8(6)13/h3-5,14H,2H2,1H3,(H2,9,10,11)/t5-/m1/s1

InChIKey

MJZYTEBKXLVLMY-RXMQYKEDSA-N

LogP

-0.21069999999999994

Topological Polar Surface Area

89.85000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 6

Complexity

202

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

(R)-9-(2-Hydroxypropyl)adenine (Desphosphoryltenofovir)
9H-Purine-9-ethanol, 6-amino-alpha-methyl-, (alphaR)-
9-(2-Hydroxypropyl)adenine, (R)-
D-(-)-9-(2-HYDROXYPROPYL)ADENINE
(R)-9-(2-hydroxypropyl)adenine, AldrichCPR
DB02765
(R)-9-[2-(Hydroxypropyl] Adenine(Desphosphoryl Tenofovir)
(R)-9-(2-Hydroxypropyl)adenine
(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol
AKOS006286534
AKOS015855516
9H-PURINE-9-ETHANOL, 6-AMINO-.ALPHA.-METHYL-, (.ALPHA.R)-
(R)-(+)-9-(2-HYDROXYPROPYL)ADENINE
MJZYTEBKXLVLMY-RXMQYKEDSA-N
9H-PURINE-9-ETHANOL, 6-AMINO-.ALPHA.-METHYL-, (R)-
9H-Purine-9-ethanol, 6-amino-alpha-methyl-, D-
UNII-43H6SBP55W
R-9-(2-hydroxypropyl)adenine [WHO-DD]
(R)-9-[2-(hydroxy)propyl]adenine
14047-28-0
SCHEMBL1393316
CS-0040479
H1291
(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol
AMY40726
MFCD07369451
NS00068869
(r)-9-[2-(hydroxyl)propyl]adenine
9H-PURINE-9-ETHANOL, 6-AMINO-.ALPHA.-METHYL-, D-
9H-Purine-9-ethanol, 2-amino-.alpha.-methyl-, (a9R)-
(R)-6-Amino-9-(2-hydroxypropyl)purine

MDL Number

MFCD07369451

Customs Code

2933990090

FAQ

What is (2R)-1-(6-Amino-9H-purin-9-yl)-2-propanol (CAS: 14047-28-0)?

This compound, with the CAS number 14047-28-0, is a nucleoside analog characterized by its chemical structure featuring a purine ring substituted with an amino group at position 6, connected to a 2-propanol moiety. It is a white solid with high water solubility and is commonly used in pharmaceutical research for its potential biological activity. Its molecular formula is C8H12N5O, and it exhibits specific stereochemistry due to the (2R) configuration.

What are the main uses of (2R)-1-(6-Amino-9H-purin-9-yl)-2-propanol (CAS: 14047-28-0)?

The compound is primarily utilized in pharmaceutical applications, such as the development of antiviral and antitumor drugs, due to its structural similarity to nucleosides. It serves as a key intermediate in research related to nucleic acid metabolism and is also employed in the synthesis of other bioactive compounds. Its versatility makes it valuable in medicinal chemistry and biochemical studies.

Is (2R)-1-(6-Amino-9H-purin-9-yl)-2-propanol (CAS: 14047-28-0) safe?

Safety data for this compound indicates it is generally low in toxicity when handled properly. However, standard laboratory precautions, such as wearing gloves, goggles, and a lab coat, are recommended to avoid skin or eye contact. It is advisable to consult its safety data sheet (SDS) for detailed toxicity information and regulatory guidelines, especially in industrial or research settings.

How should (2R)-1-(6-Amino-9H-purin-9-yl)-2-propanol (CAS: 14047-28-0) be stored?

This compound should be stored in a cool, dry place, away from light, in a sealed container to maintain stability. It is recommended to keep it at temperatures below 25°C and ensure humidity levels are controlled to prevent degradation. Storage under an inert atmosphere may also be necessary, and adherence to specific container requirements is essential for long-term preservation.