(2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-phenylbutanoic acid | CAS No. 135944-09-1
(2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-phenylbutanoic acid
Basic Information
CAS Number
135944-09-1
Molecular Formula
C25H23NO4
Molecular Weight
401.46 g/mol
AD
Basic Physical Properties
Boiling Point
628.3℃ at 760 mmHg
Flash Point
333.8℃
Safety Information
View Safety InformationHazard Class
Class IRRITANT
Class IRRITANT
Synonyms & References
English
- Z1741978682
- FMOC-D-HOMOPHE
- AC-9970
- 135944-09-1
- (R)-2-(((9H-FLUOREN-9-YL)METHOXY)CARBONYLAMINO)-4-PHENYLBUTANOIC ACID
- Fmoc-D-Homophe-OH, >=98.0% (HPLC)
- (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-phenylbutanoic acid
- 135994-09-1
- HY-W002436
- FMOC-D-HOPHE-OH
- Fmoc-DL--Me-Phe-OH
- EN300-317076
- (R)-2-(Fmoc-amino)-4-phenylbutyric acid
- Fmoc-D-homophenylalanine (Fmoc-D-hPhe-OH)
- MFCD00151917
- Fmoc-D-Homophe-OH
- (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-phenylbutanoic acid
- FMOC-D-HPHE-OH
- DS-1154
- AKOS015912368
- CS-W002436
- CIHPCIUGLIZADU-HSZRJFAPSA-N
- SCHEMBL800091
- FMOC-D-HOMOPHENYL-ALA
- (R)-alpha-[N-(9-Fluorenylmethoxycarbonyl)amino]-benzenebutanoic acid
- A886911
- (R)-2-((((9H-FLUOREN-9-YL)METHOXY)CARBONYL)AMINO)-4-PHENYLBUTANOIC ACID
- DTXSID30427842
- AM20050372
- J-300429
- Fmoc-D-homophenylalanine
MDL Number
MFCD00151917
Customs Code
2924299090
FAQ
What are the physical and chemical properties of (2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-phenylbutanoic acid (CAS: 135944-09-1)?
The compound is a white to off-white crystalline solid with a molecular weight of approximately 432.4 g/mol. It is sparingly soluble in water but soluble in organic solvents. Chemically, it is stable under normal conditions but can be sensitive to strong bases and heat. It can undergo acylation and amide formation reactions.
How is (2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-phenylbutanoic acid (CAS: 135944-09-1) typically synthesized?
It is synthesized through multi-step processes involving coupling of fluorenylmethanol with an amino acid via a Fmoc (fluorenylmethoxycarbonyl) strategy. The key steps include protection of the amino group, coupling with the fluorenylmethoxycarbonyl group, and subsequent deprotection to form the final product. The overall yield is around 70%.
What industries use (2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-phenylbutanoic acid (CAS: 135944-09-1)?
This compound is primarily used in pharmaceuticals for the synthesis of certain drugs due to its specific functional groups. It is also used in the polymer industry for the modification of polymer surfaces and in the semiconductor industry for the production of photoresists.
What precautions should be taken when handling (2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-phenylbutanoic acid (CAS: 135944-09-1)?
When handling this compound, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be managed using appropriate absorbents, and the compound should be stored in a cool, dry place away from strong acids and bases. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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