3-Hydroxy-N-(2-naphthyl)-2-naphthamide

Basic Information

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CAS Number

135-64-8

Molecular Formula

C21H15NO2

Molecular Weight

313.36 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

243~244℃

Boiling Point

479.254°C at 760 mmHg

Density

1.3±0.1 g/cm3

Flash Point

243.6±24.0 °C

Refractive Index

1.778

Vapor Pressure

0.0±1.2 mmHg at 25°C

SMILES

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C1=CC=C2C=C(C=CC2=C1)NC(=O)C3=CC4=CC=CC=C4C=C3O

InChI

InChI=1S/C21H15NO2/c23-20-13-17-8-4-3-7-16(17)12-19(20)21(24)22-18-10-9-14-5-1-2-6-15(14)11-18/h1-13,23H,(H,22,24)

InChIKey

PMYDPQQPEAYXKD-UHFFFAOYSA-N

LogP

4.9509000000000025

Topological Polar Surface Area

49.33 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

451

Synonyms & References

English

Cibanaphthol RA
MFCD00053488
SCHEMBL2681852
A806964
Naphthol AS-SW
3-Hydroxy-N-(2-naphthyl)-2-naphthamide
Naphthol AS-SW Dispersible
135-64-8
NAFTOL AS-SW
Naphtholate AS-SW Soln
Amanil Naphthol AS-SW
2-Hydroxy-3-naphthoic Acid 2-Naphthylamide
Naphtol AS-SWN
H0319
Mitsui Naphthozol SW
C.I. 37565
NAPTHOL ASSW
Naphthanil SW
ANARTHOL AS-SW
Azoic Coupling Component 7
CONAZOIC L
Tulathol AS-SW
NSC42112
1-HYDROXY-3-NAPHTHOYL-2-NAPHTHAMINE
NAPHTHOL SW
EINECS 205-208-7
2-Naphthalenecarboxamide, 3-hydroxy-N-2-naphthalenyl-
DTXSID6059655
Dragonthol SW
3-HYDROXY-NAPHTHALENE-2-CARBOXYLIC ACID NAPHTHALEN-2-YLAMIDE
3-Hydroxy-2-naphthoic-.beta.-naphthalide

MDL Number

MFCD00053488

Customs Code

2924299090

FAQ

What are the physical and chemical properties of 3-Hydroxy-N-(2-naphthyl)-2-naphthamide (CAS: 135-64-8)?

3-Hydroxy-N-(2-naphthyl)-2-naphthamide (CAS: 135-64-8) is a crystalline compound with a molecular weight of approximately 304.25 g/mol. It has a low solubility in water but is more soluble in organic solvents such as methanol and acetonitrile. This compound is relatively stable under normal conditions but may react with strong acids or bases. It is insoluble in common organic solvents like hexanes and toluene.

How is 3-Hydroxy-N-(2-naphthyl)-2-naphthamide (CAS: 135-64-8) typically synthesized?

3-Hydroxy-N-(2-naphthyl)-2-naphthamide (CAS: 135-64-8) is typically synthesized via an amide coupling reaction of 2-naphthylamine and 3-hydroxynaphthaldehyde. The reaction is often catalyzed by a Lewis acid such as aluminum trichloride and proceeds under reflux. The yield is moderate, around 50-60%, and the product can be purified by recrystallization from water or an organic solvent.

What industries use 3-Hydroxy-N-(2-naphthyl)-2-naphthamide (CAS: 135-64-8)?

3-Hydroxy-N-(2-naphthyl)-2-naphthamide (CAS: 135-64-8) is used in the pharmaceutical industry for its potential as an intermediate in the synthesis of drugs, particularly those with analgesic and anti-inflammatory properties. It is also used in the production of dyes and pigments, as well as in the development of sensors and semiconductors due to its electronic properties.

What precautions should be taken when handling 3-Hydroxy-N-(2-naphthyl)-2-naphthamide (CAS: 135-64-8)?

When handling 3-Hydroxy-N-(2-naphthyl)-2-naphthamide (CAS: 135-64-8), it is important to wear appropriate personal protective equipment (PPE), including gloves and safety glasses. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. If a spill occurs, it should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.