3-Hydroxy-N-(2-naphthyl)-2-naphthamide(CAS: 135-64-8)

3-Hydroxy-N-(2-naphthyl)-2-naphthamide (CAS: 135-64-8) is a crystalline compound with a molecular weight of approximately 304.25 g/mol. It has a low solubility in water but is more soluble in organic solvents such as methanol and acetonitrile. This compound is relatively stable under normal conditions but may react with strong acids or bases. It is insoluble in common organic solvents like hexanes and toluene.

3-Hydroxy-N-(2-naphthyl)-2-naphthamide (CAS: 135-64-8) is typically synthesized via an amide coupling reaction of 2-naphthylamine and 3-hydroxynaphthaldehyde. The reaction is often catalyzed by a Lewis acid such as aluminum trichloride and proceeds under reflux. The yield is moderate, around 50-60%, and the product can be purified by recrystallization from water or an organic solvent.

3-Hydroxy-N-(2-naphthyl)-2-naphthamide (CAS: 135-64-8) is used in the pharmaceutical industry for its potential as an intermediate in the synthesis of drugs, particularly those with analgesic and anti-inflammatory properties. It is also used in the production of dyes and pigments, as well as in the development of sensors and semiconductors due to its electronic properties.

When handling 3-Hydroxy-N-(2-naphthyl)-2-naphthamide (CAS: 135-64-8), it is important to wear appropriate personal protective equipment (PPE), including gloves and safety glasses. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. If a spill occurs, it should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.