2,4-Dichloro-6-fluoroquinazoline

Basic Information

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CAS Number

134517-57-0

Molecular Formula

C8H3Cl2FN2

Molecular Weight

217.03 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

201.7°C at 760 mmHg

Density

1.571

Flash Point

75.8℃

Refractive Index

1.644

SMILES

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C1=CC2=C(C=C1F)C(=NC(=N2)Cl)Cl

InChI

InChI=1S/C8H3Cl2FN2/c9-7-5-3-4(11)1-2-6(5)12-8(10)13-7/h1-3H

InChIKey

VLPYLGGGYDUVJN-UHFFFAOYSA-N

LogP

3.0757000000000003

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

193

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

AB55585
MFCD09954884
2 pound not4-Dichloro-6-fluoroquinazoline
A2856
134517-57-0
DS-15021
6-fluoro-2,4-dichloroquinazoline
2,4-dichloro-6-fluoroquinazoline
W-205440
CS-W001036
2?4-dichloro-6-fluoroquinazoline
SY007266
AKOS015853535
DTXSID50586541
VLPYLGGGYDUVJN-UHFFFAOYSA-N
SCHEMBL1991118
AM20020414
FT-0682240
QUINAZOLINE, 2,4-DICHLORO-6-FLUORO-
2,4-Dichloro-6-fluoroquinazoline
4-Dichloro-6-fluoroquinazoline
Quinazoline,2,4-dichloro-6-fluoro-
PubChem14294
2,4-dichloro-6-fluoro-quinazoline
RP05030
TRA0050540
VZ22519
SY0072

MDL Number

MFCD09954884

FAQ

What are the physical and chemical properties of 2,4-Dichloro-6-fluoroquinazoline (CAS: 134517-57-0)?

2,4-Dichloro-6-fluoroquinazoline is a crystalline solid with a molecular weight of 315.03 g/mol. It has a low solubility in water, but is soluble in common organic solvents like DMSO and DMF. It shows moderate reactivity, particularly towards nucleophiles, and is generally stable under normal conditions but can hydrolyze under basic conditions.

How is 2,4-Dichloro-6-fluoroquinazoline (CAS: 134517-57-0) typically synthesized?

2,4-Dichloro-6-fluoroquinazoline is synthesized via a multi-step process starting from 2,4-dichloroquinazoline. The key steps involve fluorination of the nitrogen and subsequent chlorination, typically using reagents like hydrogen fluoride and thionyl chloride. The overall yield is around 70-80% with good selectivity.

What industries use 2,4-Dichloro-6-fluoroquinazoline (CAS: 134517-57-0)?

2,4-Dichloro-6-fluoroquinazoline is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It also finds applications in the development of sensors and semiconductors due to its unique electronic properties.

What precautions should be taken when handling 2,4-Dichloro-6-fluoroquinazoline (CAS: 134517-57-0)?

Proper personal protective equipment (PPE) including gloves, goggles, and a lab coat should be worn when handling 2,4-dichloro-6-fluoroquinazoline. Work should be carried out in a well-ventilated area or fume hood. Spills should be handled carefully, preferably using an absorbent material followed by thorough cleaning with water and appropriate waste disposal methods. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.