2,4-Dichloro-6-fluoroquinazoline(CAS: 134517-57-0)

2,4-Dichloro-6-fluoroquinazoline is a crystalline solid with a molecular weight of 315.03 g/mol. It has a low solubility in water, but is soluble in common organic solvents like DMSO and DMF. It shows moderate reactivity, particularly towards nucleophiles, and is generally stable under normal conditions but can hydrolyze under basic conditions.

2,4-Dichloro-6-fluoroquinazoline is synthesized via a multi-step process starting from 2,4-dichloroquinazoline. The key steps involve fluorination of the nitrogen and subsequent chlorination, typically using reagents like hydrogen fluoride and thionyl chloride. The overall yield is around 70-80% with good selectivity.

2,4-Dichloro-6-fluoroquinazoline is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It also finds applications in the development of sensors and semiconductors due to its unique electronic properties.

Proper personal protective equipment (PPE) including gloves, goggles, and a lab coat should be worn when handling 2,4-dichloro-6-fluoroquinazoline. Work should be carried out in a well-ventilated area or fume hood. Spills should be handled carefully, preferably using an absorbent material followed by thorough cleaning with water and appropriate waste disposal methods. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.