N-Trityl Losartan

Basic Information

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CAS Number

133909-99-6

Molecular Formula

C41H37ClN6O

Molecular Weight

665.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

171-176°C

SMILES

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CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN(N=N4)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)CO)Cl

InChI

InChI=1S/C41H37ClN6O/c1-2-3-23-38-43-39(42)37(29-49)47(38)28-30-24-26-31(27-25-30)35-21-13-14-22-36(35)40-44-46-48(45-40)41(32-15-7-4-8-16-32,33-17-9-5-10-18-33)34-19-11-6-12-20-34/h4-22,24-27,49H,2-3,23,28-29H2,1H3

InChIKey

QQPGGBNMTNDKEY-UHFFFAOYSA-N

LogP

8.580400000000003

Topological Polar Surface Area

81.65 Å²

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

932

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AC-1071
Trityl losartan
N-Trityl Losartan (Losartan Impurity H)
N-Trityl Losartan
AKOS015895667
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl) -1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol
2-n-Butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl -4-yl)methyl]-1H-imidazole-5-methanol
J-006452
UNII-N0UJG23A3Y
N0UJG23A3Y
Trityllosartan
Losartan potassium impurity H [EP]
NS00003947
N-Trityllosartan
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol
2-Butyl-4-chloro-5-hydroxymethyl-1-((2'-(1H-2-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl)imidazole
[2-Butyl-4-chloro-1-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl]biphenyl-4-yl]methyl]-1H-imidazol-5-yl]methanol
[2-butyl-5-chloro-3-[[4-[2-(2-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
2-n-Butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]1H-imidazole-5-methanol
SCHEMBL3407499
FT-0656123
EC 412-420-5
QQPGGBNMTNDKEY-UHFFFAOYSA-N
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(2-(triphenylmethyl)-2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-
LOSARTAN POTASSIUM IMPURITY H [EP IMPURITY]
MFCD09028113
(2-Butyl-4-chloro-1-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazol-5-yl)methanol
Losartan Potassium Imp. H (EP); Losartan Imp. H (EP); [2-Butyl-4-chloro-1-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl]biphenyl-4-yl]methyl]-1H-imidazol-5-yl]methanol; Losartan Potassium Impurity H; Losartan Impurity H
N2-Trityllosartan
BCP12002
DTXSID80158417

MDL Number

MFCD09028113

Customs Code

2933990090

FAQ

What are the physical and chemical properties of N-Trityl Losartan (CAS: 133909-99-6)?

N-Trityl Losartan (CAS: 133909-99-6) is a crystalline compound with a molecular weight of approximately 406.38 g/mol. It has a solubility of about 0.8 mg/mL in water and is relatively stable under normal storage conditions. The compound is reactive towards nucleophiles and can undergo substitution reactions. It does not typically react with acids or bases under normal conditions.

How is N-Trityl Losartan (CAS: 133909-99-6) typically synthesized?

N-Trityl Losartan (CAS: 133909-99-6) is synthesized through a multi-step process involving the tritylation of the hydroxyl group of losartan. Common catalysts include triphenylphosphine and imidazole. The synthesis yields are typically around 85-90%, and the process involves protecting the functional groups to avoid side reactions.

What industries use N-Trityl Losartan (CAS: 133909-99-6)?

N-Trityl Losartan (CAS: 133909-99-6) is primarily used in the pharmaceutical industry for its role as an intermediate in the synthesis of losartan, an antihypertensive drug. It is also utilized in the chemical industry for its reactivity and stability in various chemical reactions.

What precautions should be taken when handling N-Trityl Losartan (CAS: 133909-99-6)?

When handling N-Trityl Losartan (CAS: 133909-99-6), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be handled with care, using appropriate absorbent materials, and the area should be cleaned according to standard safety protocols. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage information.