2-Chloro-7-methoxy-3-methylquinoline

Basic Information

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CAS Number

132118-45-7

Molecular Formula

C11H10ClNO

Molecular Weight

207.66 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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CC1=CC2=C(C=C(C=C2)OC)N=C1Cl

InChI

InChI=1S/C11H10ClNO/c1-7-5-8-3-4-9(14-2)6-10(8)13-11(7)12/h3-6H,1-2H3

InChIKey

KVBVZTHTUJBHOF-UHFFFAOYSA-N

LogP

3.2052200000000015

Topological Polar Surface Area

22.12 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

200

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

Synonyms & References

English

2-Chloro-7-methoxy-3-methylquinoline
AB51977
AGN-PC-00Q1DY
AK126965
CTK8E3981
MolPort-006-170-869
OTAVA-BB 1151708
2-CHLORO-7-METHOXY-3-METHYLQUINOLINE
132118-45-7
DTXSID50576149
DA-12324
EN300-7436787
KVBVZTHTUJBHOF-UHFFFAOYSA-N
MFCD09787682
CS-0217429
SCHEMBL6033527
Quinoline, 2-chloro-7-methoxy-3-methyl-
2-Chloro-7-methoxy-3-methylquinoline, AldrichCPR
AKOS002676315

MDL Number

MFCD09787682

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 2-Chloro-7-methoxy-3-methylquinoline (CAS: 132118-45-7)?

2-Chloro-7-methoxy-3-methylquinoline is a crystalline solid with a molecular weight of approximately 261.67 g/mol. It has a high melting point of around 175-177°C. The compound is slightly soluble in water but readily soluble in organic solvents such as ethanol and acetone. Chemically, it is less reactive compared to other quinoline derivatives but can undergo electrophilic aromatic substitution reactions easily. It is often used in the synthesis of pharmaceuticals and other organic compounds.

How is 2-Chloro-7-methoxy-3-methylquinoline (CAS: 132118-45-7) typically synthesized?

2-Chloro-7-methoxy-3-methylquinoline is typically synthesized via the Friedel-Crafts alkylation of 7-methoxy-3-methylquinoline with chlorine. The reaction is catalyzed by aluminum chloride and proceeds with good yield. The use of a fume hood is essential due to the volatility of chlorine. The process requires careful control of temperature and reaction time to achieve high selectivity and yield.

What industries use 2-Chloro-7-methoxy-3-methylquinoline (CAS: 132118-45-7)?

2-Chloro-7-methoxy-3-methylquinoline is primarily used in the pharmaceutical industry for the synthesis of various bioactive compounds. It also finds applications in the polymer industry for the development of advanced materials. Additionally, it is utilized in the production of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 2-Chloro-7-methoxy-3-methylquinoline (CAS: 132118-45-7)?

When handling 2-Chloro-7-methoxy-3-methylquinoline, safety goggles, gloves, and lab coats should be worn. Work in a fume hood to minimize exposure to chlorine gas. Spills should be cleaned up immediately with appropriate absorbent materials. In case of skin contact, wash the affected area with soap and water. Always refer to the Safety Data Sheet (SDS) for detailed emergency response procedures. Proper storage should be in a cool, dry place away from heat sources and incompatible materials.