Compound Q&A
How is 2-Chloro-7-methoxy-3-methylquinoline (CAS: 132118-45-7) typically synthesized?
Answer
2-Chloro-7-methoxy-3-methylquinoline is typically synthesized via the Friedel-Crafts alkylation of 7-methoxy-3-methylquinoline with chlorine. The reaction is catalyzed by aluminum chloride and proceeds with good yield. The use of a fume hood is essential due to the volatility of chlorine. The process requires careful control of temperature and reaction time to achieve high selectivity and yield.
About
CAS No
132118-45-7
English Name
2-Chloro-7-methoxy-3-methylquinoline
Molecular Formula
C11H10ClNO
Molecular Weight
207.66 g/mol
SMILES
CC1=CC2=C(C=C(C=C2)OC)N=C1Cl
InChIKey
KVBVZTHTUJBHOF-UHFFFAOYSA-N
Last Updated: 2026-01-13 15:28
