2-Chloro-7-methoxy-3-methylquinoline(CAS: 132118-45-7)

2-Chloro-7-methoxy-3-methylquinoline is a crystalline solid with a molecular weight of approximately 261.67 g/mol. It has a high melting point of around 175-177°C. The compound is slightly soluble in water but readily soluble in organic solvents such as ethanol and acetone. Chemically, it is less reactive compared to other quinoline derivatives but can undergo electrophilic aromatic substitution reactions easily. It is often used in the synthesis of pharmaceuticals and other organic compounds.

2-Chloro-7-methoxy-3-methylquinoline is typically synthesized via the Friedel-Crafts alkylation of 7-methoxy-3-methylquinoline with chlorine. The reaction is catalyzed by aluminum chloride and proceeds with good yield. The use of a fume hood is essential due to the volatility of chlorine. The process requires careful control of temperature and reaction time to achieve high selectivity and yield.

2-Chloro-7-methoxy-3-methylquinoline is primarily used in the pharmaceutical industry for the synthesis of various bioactive compounds. It also finds applications in the polymer industry for the development of advanced materials. Additionally, it is utilized in the production of sensors and semiconductors due to its unique chemical properties.

When handling 2-Chloro-7-methoxy-3-methylquinoline, safety goggles, gloves, and lab coats should be worn. Work in a fume hood to minimize exposure to chlorine gas. Spills should be cleaned up immediately with appropriate absorbent materials. In case of skin contact, wash the affected area with soap and water. Always refer to the Safety Data Sheet (SDS) for detailed emergency response procedures. Proper storage should be in a cool, dry place away from heat sources and incompatible materials.