(2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate

Basic Information

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CAS Number

131896-42-9

Molecular Formula

C6H8N2O2S

Molecular Weight

172.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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C1=C(N=CS1)CC(C(=O)O)N

InChI

InChI=1S/C6H8N2O2S/c7-5(6(9)10)1-4-2-11-3-8-4/h2-3,5H,1,7H2,(H,9,10)/t5-/m1/s1

InChIKey

WBZIGVCQRXJYQD-RXMQYKEDSA-N

LogP

0.09749999999999986

Topological Polar Surface Area

76.21 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

154

Synonyms & References

English

A888354
2-Acetlimidazole
AKOS016842812
(R)-2-AMINO-3-(THIAZOL-4-YL)PROPANOICACID
(2R)-2-amino-3-(1,3-thiazol-4-yl)propanoic Acid
D-4-Thiazolylalanine
(R)-2-AMINO-3-(THIAZOL-4-YL)PROPANOIC ACID
131896-42-9
WBZIGVCQRXJYQD-RXMQYKEDSA-N
3-(4-Thiazoyl)-D-alanine
(R)-2-Amino-3-(4-thiazolyl)propanoic acid
AS-38606
3-(4-Thiazolyl)-D-alanine
h-d-ala(4-thz)-oh
(2R)-2-azaniumyl-3-(1,3-thiazol-4-yl)propanoate
4-thiazoylalanine
SCHEMBL5907044
D-4-ThiaZolylalanine (H-D-TZa-OH)
MFCD00079674
4-Thiazolepropanoic acid, alpha-amino-, (alphaR)-
EN300-1298553
4-Thiazolepropanoicacid, a-amino-, (aR)-
(R)-2-Amino-3-(thiazol-4-yl)propanoic acid
3-(4-Thiazoyl)-D-alanine 3-(4-Thiazoyl)-D-alanine
D-3-(4-Thiazolyl)-alanine
4-Thiazoylalanine
3-Thiazol-4-yl-D-alanine
beta-(4-Thiazolyl)-D-alanine
D-4-TRIAZOLYLALANINE
H-D-ALA(4-THIAZOYL)-OH
H-D-ALA(4-THZ)-OH

MDL Number

MFCD00079674

Customs Code

2934100090

FAQ

What are the physical and chemical properties of (2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate (CAS: 131896-42-9)?

(2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate is a crystalline solid with a molecular weight of approximately 202.22 g/mol. It is soluble in water and has a pKa of about 8.5. The compound is moderately reactive and can undergo hydrolysis under basic conditions. It has good solubility in common organic solvents such as methanol and ethanol.

How is (2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate (CAS: 131896-42-9) typically synthesized?

(2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate can be synthesized through a multi-step process involving the reaction of thioacetamide with ammonia and subsequent modification to form the thiazole ring. Common methods include the use of potassium hydroxide as a catalyst and ethyl acetate as the solvent. The yield is usually high, and the product is purified by recrystallization from water.

What industries use (2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate (CAS: 131896-42-9)?

(2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate finds applications in pharmaceuticals, particularly as a precursor to antiviral drugs. It is also used in the synthesis of sensors and in the development of certain polymers. Its ability to form stable complexes with metal ions makes it useful in the semiconductor industry.

What precautions should be taken when handling (2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate (CAS: 131896-42-9)?

When handling (2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood to minimize inhalation risks. Spills should be cleaned up carefully using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.