(2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate(CAS: 131896-42-9)

(2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate is a crystalline solid with a molecular weight of approximately 202.22 g/mol. It is soluble in water and has a pKa of about 8.5. The compound is moderately reactive and can undergo hydrolysis under basic conditions. It has good solubility in common organic solvents such as methanol and ethanol.

(2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate can be synthesized through a multi-step process involving the reaction of thioacetamide with ammonia and subsequent modification to form the thiazole ring. Common methods include the use of potassium hydroxide as a catalyst and ethyl acetate as the solvent. The yield is usually high, and the product is purified by recrystallization from water.

(2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate finds applications in pharmaceuticals, particularly as a precursor to antiviral drugs. It is also used in the synthesis of sensors and in the development of certain polymers. Its ability to form stable complexes with metal ions makes it useful in the semiconductor industry.

When handling (2R)-2-Ammonio-3-(1,3-thiazol-4-yl)propanoate, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood to minimize inhalation risks. Spills should be cleaned up carefully using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.