8-Bromo-5,6-difluoro-2-methylquinoline

Basic Information

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CAS Number

131190-82-4

Molecular Formula

C10H6BrF2N

Molecular Weight

258.07 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

SMILES

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Cc1ccc2c(n1)c(Br)cc(c2F)F

InChI

InChI=1S/C10H6BrF2N/c1-5-2-3-6-9(13)8(12)4-7(11)10(6)14-5/h2-4H,1H3

InChIKey

YPKUTBCKHJBNKX-UHFFFAOYSA-N

LogP

3.583920000000001

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H320 Causes eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

8-Bromo-5,6-difluoro-2-methylquinoline
ACT08138
AG-D-63316
AK-57571
ANW-58912
CTK4B7135
KB-200284
SureCN4059605
8-bromo-5,6-difluoro-2-methylquinoline

MDL Number

MFCD08705815

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 8-Bromo-5,6-difluoro-2-methylquinoline (CAS: 131190-82-4)?

8-Bromo-5,6-difluoro-2-methylquinoline is a white to off-white crystalline solid with a molecular weight of 251.02 g/mol. It has a low solubility in water but is soluble in common organic solvents like ethanol and acetone. The compound is known for its high stability but can undergo substitution reactions under appropriate conditions. It is generally reactive towards nucleophiles and electrophiles.

How is 8-Bromo-5,6-difluoro-2-methylquinoline (CAS: 131190-82-4) typically synthesized?

8-Bromo-5,6-difluoro-2-methylquinoline is typically synthesized through a multi-step process involving the protection of a quinoline ring, introduction of bromine and fluorine substituents, and the subsequent deprotection. Commonly used reactions include bromination of 5,6-difluoro-2-methylquinoline followed by quenching and purification steps. The yield from these reactions can be controlled by the choice of solvents and reaction conditions.

What industries use 8-Bromo-5,6-difluoro-2-methylquinoline (CAS: 131190-82-4)?

8-Bromo-5,6-difluoro-2-methylquinoline is used primarily in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various bioactive compounds, including drugs. In addition, it is also utilized in the development of organic sensors and functional materials due to its unique chemical properties.

What precautions should be taken when handling 8-Bromo-5,6-difluoro-2-methylquinoline (CAS: 131190-82-4)?

When handling 8-Bromo-5,6-difluoro-2-methylquinoline, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be carefully cleaned up using suitable absorbents, and proper disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for detailed precautions and emergency procedures.