2-Methyl-2-propanyl (7R)-5-azaspiro[2.4]hept-7-ylcarbamate

Basic Information

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CAS Number

127199-44-4

Molecular Formula

C11H20N2O2

Molecular Weight

212.29 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

329°C at 760 mmHg

Flash Point

152.791 °C

SMILES

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CC(C)(C)OC(=O)NC1CNCC12CC2

InChI

InChI=1S/C11H20N2O2/c1-10(2,3)15-9(14)13-8-6-12-7-11(8)4-5-11/h8,12H,4-7H2,1-3H3,(H,13,14)/t8-/m0/s1

InChIKey

CGEBPOMWRHSMLI-QMMMGPOBSA-N

LogP

1.2630999999999997

Topological Polar Surface Area

50.36 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

266

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

CFA19944
(R)-(5-Aza-spiro[2.4]hept-7-yl)-carbamic acid tert-butyl ester
AC-31191
AKOS015898045
DTXSID50435666
Carbamic acid, (7R)-5-azaspiro[2.4]hept-7-yl-, 1,1-dimethylethyl ester (9CI)
FD6059
SCHEMBL12276525
DS-15111
(R)-tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate
tert-Butyl (R)-(5-azaspiro[2.4]heptan-7-yl)carbamate
(R)-7-(BOC-AMINO)-5-AZASPIRO[2.4]HEPTANE
Carbamic acid, N-(7R)-5-azaspiro[2.4]hept-7-yl-, 1,1-dimethylethyl ester
AKOS015995008
TERT-BUTYL N-[(7R)-5-AZASPIRO[2.4]HEPTAN-7-YL]CARBAMATE
CS-W021148
MFCD11519122
AMY5824
Carbamic acid,(7R)-5-azaspiro[2.4]hept-7-yl-,1,1-dimethylethyl ester(9ci)
CGEBPOMWRHSMLI-QMMMGPOBSA-N
tert-Butyl (7R)-5-azaspiro[2.4]heptan-7-ylcarbamate
127199-44-4
tert-butyl N-[(7R)-5-azaspiro[2.4]heptan-7-yl]carbamate
(R)-7-tert-Butoxycarbonylamino-5-azaspiro[2.4]heptane
Sitafloxacin Impurity 13
N-(7R)-5-Azaspiro[2.4]hept-7-yl-carbamic acid 1,1-dimethylethyl ester
PubChem11455
RP26688
LS30007
CM10022
PB19151

MDL Number

MFCD11519122

FAQ

What are the physical and chemical properties of 2-Methyl-2-propanyl (7R)-5-azaspiro[2.4]hept-7-ylcarbamate (CAS: 127199-44-4)?

The compound is an oily liquid at room temperature with a molecular weight of approximately 212.3 g/mol. It has a low water solubility and moderate solubility in organic solvents. It is relatively stable under normal conditions but can react with strong bases. Chemical properties include its ability to form salts and its reactivity in nucleophilic substitution reactions.

How is 2-Methyl-2-propanyl (7R)-5-azaspiro[2.4]hept-7-ylcarbamate (CAS: 127199-44-4) typically synthesized?

The compound is typically synthesized via a multistep process involving the protection of a primary amine, followed by cyclization and deprotection. Common reagents include tert-butyldimethylsilyl chloride and various bases. The synthesis involves careful control of pH and temperature to achieve high yields and selectivity.

What industries use 2-Methyl-2-proanyl (7R)-5-azaspiro[2.4]hept-7-ylcarbamate (CAS: 127199-44-4)?

This compound is primarily used in pharmaceutical research as a scaffolding molecule for drug discovery. It may also have applications in the synthesis of certain polymers and as a reagent in organic synthesis. Its use in semiconductors and sensors is less common but possible due to its chemical versatility.

What precautions should be taken when handling 2-Methyl-2-proanyl (7R)-5-azaspiro[2.4]hept-7-ylcarbamate (CAS: 127199-44-4)?

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling the compound. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up carefully with absorbent materials and appropriate waste disposal procedures followed. Always consult the Safety Data Sheet (SDS) for detailed safety information.