Evolocumab | CAS No. 1256937-27-5

Evolocumab

Basic Information

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CAS Number

1256937-27-5

Molecular Formula

C58H97N15O16S2Se

Molecular Weight

1403.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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C[C@@H]1CC=N[C@H]1C(=NCCCC[C@@H](C(=O)C(=O)[C@H](CS)NN[C@@H](C[SeH])C(=O)C(=O)[C@H](CCSC)N=C([C@H](C)NN[C@@H](CC(=N)O)C(=O)O)O)N=C([C@H](CC(C)C)N=C([C@H](CCCCN=C([C@H]2[C@@H](CC=N2)C)O)N=C([C@H](C(C)C)N=C([C@H](CCC(=O)O)N)O)O)O)O)O

InChI

InChI=1S/C58H97N15O16S2Se/c1-29(2)25-38(68-53(83)37(14-10-12-21-64-56(86)46-32(6)18-23-62-46)67-57(87)44(30(3)4)69-52(82)34(59)15-16-43(75)76)54(84)66-35(13-9-11-20-63-55(85)45-31(5)17-22-61-45)47(77)49(79)40(27-90)72-73-41(28-92)50(80)48(78)36(19-24-91-8)65-51(81)33(7)70-71-39(58(88)89)26-42(60)74/h22-23,29-41,44-46,70-73,90,92H,9-21,24-28,59H2,1-8H3,(H2,60,74)(H,63,85)(H,64,86)(H,65,81)(H,66,84)(H,67,87)(H,68,83)(H,69,82)(H,75,76)(H,88,89)/t31-,32-,33+,34+,35+,36+,37+,38+,39+,40+,41+,44+,45-,46-/m1/s1

InChIKey

HSSNUIIWBIUJJV-WKJVYGORSA-N

LogP

3.6891699999999994

Topological Polar Surface Area

513.9500000000002 Å²

Hydrogen Bond Donor/Acceptor

17 / 31

Synonyms & References

English

Evolocumab
AMG 145

FAQ

What is Evolocumab (CAS: 1256937-27-5)?

Evolocumab (CAS: 1256937-27-5) is a monoclonal antibody used in the treatment of hypercholesterolemia and heterozygous familial hypercholesterolemia. It is administered subcutaneously and works by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9), which reduces low-density lipoprotein (LDL) cholesterol levels.

What are the main uses of Evolocumab (CAS: 1256937-27-5)?

Evolocumab (CAS: 1256937-27-5) is primarily used to lower low-density lipoprotein (LDL) cholesterol in patients with hypercholesterolemia and heterozygous familial hypercholesterolemia. It is especially beneficial for those who do not achieve adequate cholesterol levels with statins or who cannot tolerate statins.

Is Evolocumab (CAS: 1256937-27-5) safe?

Evolocumab (CAS: 1256937-27-5) is generally considered safe. However, like all medications, it may cause side effects such as injection site reactions, headache, and injection-related itching. Precautions should be taken to avoid hypersensitivity reactions and to monitor patients for any adverse effects.

How should Evolocumab (CAS: 1256937-27-5) be stored?

Evolocumab (CAS: 1256937-27-5) should be stored refrigerated at 2 to 8°C (36 to 46°F) and should not be frozen. It should be protected from light and kept in its original package to maintain its stability. Unused vials should be discarded if they are not used within 28 days after first use.