Clarithromycin F

Basic Information

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CAS Number

124412-58-4

Molecular Formula

C38H69NO14

Molecular Weight

764 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)CO)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)O)(C)O

InChI

InChI=1S/C38H69NO14/c1-14-26-38(9,46)31(43)21(4)28(41)19(2)16-37(8,48-13)33(53-35-29(42)25(39(10)11)15-20(3)49-35)22(5)30(24(18-40)34(45)51-26)52-27-17-36(7,47-12)32(44)23(6)50-27/h19-27,29-33,35,40,42-44,46H,14-18H2,1-13H3/t19-,20-,21+,22-,23+,24+,25+,26-,27+,29-,30+,31+,32+,33+,35+,36-,37-,38?/m1/s1

InChIKey

JDKPAXGOJMGSAE-OKRVCPMNSA-N

LogP

1.4121000000000057

Topological Polar Surface Area

203.14 Å²

Hydrogen Bond Donor/Acceptor

5 / 15

Complexity

1210

Synonyms & References

English

(3S,4S,5R,6S,7R,9R,11R,12S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3-(hydroxymethyl)-7-methoxy-5,7,9,11,13-pentamethyl-oxacyclotetradecane-2,10-dione
Clarithromycin F
16-Hydroxyclarithromycin
16-OH-Clr
124412-58-4
Erythromycin,16-hydroxy-6-O-methyl-
16-hydroxyclarithromycin
6-{[4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-[(3-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy]-3-(hydroxymethyl)-7-methoxy-5,7,9,11,13-pentamethyloxacyclotetradecane-2,10-dione (non-preferred name)

FAQ

What are the physical and chemical properties of Clarithromycin F (CAS: 124412-58-4)?

Clarithromycin F is a semi-synthetic macrolide antibiotic with a molecular weight of approximately 826.94 g/mol. Its crystalline form has a solubility of about 5 mg/mL in water. Clarithromycin F is relatively stable under normal temperature and pressure conditions, but it can undergo hydrolysis in alkaline conditions. It is used in pharmaceutical formulations and is also known for its antimicrobial activity.

How is Clarithromycin F (CAS: 124412-58-4) typically synthesized?

Clarithromycin F is typically synthesized through a series of chemical reactions, including condensation, reduction, and cyclization steps. The synthesis often involves using tetracyclines as a starting material and employing specific catalysts and solvents to ensure high selectivity and yield. The process requires precise control of reaction conditions to achieve the desired product.

What industries use Clarithromycin F (CAS: 124412-58-4)?

Clarithromycin F is primarily used in the pharmaceutical industry for developing antibiotics. It is also utilized in research applications, particularly in studies related to antimicrobial activity and molecular biology. Additionally, it has potential applications in the food industry as a preservative and in the agricultural sector for controlling bacterial infections in livestock.

What precautions should be taken when handling Clarithromycin F (CAS: 124412-58-4)?

When handling Clarithromycin F, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety glasses. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up promptly using absorbent materials, and the area should be properly decontaminated. Safety data sheets (SDS) should be consulted for detailed guidelines on handling and disposal. Storage should be in a cool, dry place, away from direct sunlight and heat sources.