Azasetron HCl | CAS No. 123040-16-4

Azasetron HCl

Basic Information

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CAS Number

123040-16-4

Molecular Formula

C17H21Cl2N3O3

Molecular Weight

386.28 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

281° (dec); mp 305° (dec) (Kawakita)

SMILES

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CN1C(=O)COC2=C(C=C(C=C21)Cl)C(=O)NC3CN4CCC3CC4.Cl

InChI

InChI=1S/C17H20ClN3O3.ClH/c1-20-14-7-11(18)6-12(16(14)24-9-15(20)22)17(23)19-13-8-21-4-2-10(13)3-5-21;/h6-7,10,13H,2-5,8-9H2,1H3,(H,19,23);1H

InChIKey

DBMKBKPJYAHLQP-UHFFFAOYSA-N

LogP

1.9410000000000003

Topological Polar Surface Area

61.88 Å²

Hydrogen Bond Donor/Acceptor

1 / 6

Complexity

523

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Toxicity

LD50 in male, female rats (mg/kg): 135, 132 i.v. (Takagi)

Synonyms & References

English

123040-94-8
2H-1,4-Benzoxazine-8-carboxamide, N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-, hydrochloride (1:1)
Q27254532
SR-01000597808
Azasetron hydrochloride (JAN)
Azasetron hydrochloride [JAN]
BCP12756
azasetron hydrochloride
123040-93-7
2H-1,4-Benzoxazine-8-carboxamide,N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-,monohydrochloride, (-)-
Y-25130
AZASETRON HYDROCHLORIDE [WHO-DD]
2BSS7XL60S
2H-1,4-Benzoxazine-8-carboxamide, N-1-azabicyclo(2.2.2)oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-, monohydrochloride
AZASETRON HYDROCHLORIDE [MART.]
123040-16-4
D-erythro-Sphingosine (Brain, Porcine)
AKOS015914040
FT-0662373
SCHEMBL442156
N-{1-azabicyclo[2.2.2]octan-3-yl}-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride
J-004884
ARAZASETRON HYDROCHLORIDE, (+/-)-
AKOS005766024
(-)-Azasetron hydrochloride
YEA04016
(-)-6-Chloro-4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid (1-aza-bicyclo[2.2.2]oct-3-yl)-amide hydrochloride
477243-03-1
s2106
2H-1,4-Benzoxazine-8-carboxamide,N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-,monohydrochloride, (+)-
MLS006011207

MDL Number

MFCD00209913

FAQ

What is Azasetron HCl (CAS: 123040-16-4)?

Azasetron HCl is a selective 5-hydroxytryptamine 3 (5-HT3) receptor antagonist with antiemetic properties. It has a molecular formula of C16H18ClN3O and a molecular weight of approximately 292.76. This compound is commonly used in the treatment of chemotherapy-induced nausea and vomiting.

What are the main uses of Azasetron HCl (CAS: 123040-16-4)?

Azasetron HCl (CAS: 123040-16-4) is primarily used as a therapeutic agent to prevent and treat chemotherapy-induced nausea and vomiting. It is also studied for its potential in managing other forms of nausea and vomiting, such as those associated with radiation therapy and post-surgical conditions.

Is Azasetron HCl (CAS: 123040-16-4) safe?

Azasetron HCl (CAS: 123040-16-4) is generally considered safe when used as directed. However, it may cause side effects such as constipation, diarrhea, and headache. It is important to follow medical advice and use under the supervision of a healthcare professional. Always read the product label and follow safety guidelines.

How should Azasetron HCl (CAS: 123040-16-4) be stored?

Azasetron HCl (CAS: 123040-16-4) should be stored at room temperature between 15-30°C (59-86°F). Keep the container tightly closed to protect it from moisture and light. Store it out of reach of children and pets. Do not freeze or expose to high temperatures. Use appropriate containers to prevent degradation and ensure the safety and efficacy of the product.