Benzyl 4-(hydroxymethyl)-1-piperidinecarboxylate

Basic Information

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CAS Number

122860-33-7

Molecular Formula

C14H19NO3

Molecular Weight

249.31 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

Sticky Oil to Solid

Boiling Point

396.4°C at 760 mmHg

Density

1.162

Flash Point

193.5℃

Refractive Index

1.549

SMILES

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C1CN(CCC1CO)C(=O)OCC2=CC=CC=C2

InChI

InChI=1S/C14H19NO3/c16-10-12-6-8-15(9-7-12)14(17)18-11-13-4-2-1-3-5-13/h1-5,12,16H,6-11H2

InChIKey

LINIORCIRVAZSM-UHFFFAOYSA-N

LogP

2.0275

Topological Polar Surface Area

49.769999999999996 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

256

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

122860-33-7
4-Hydroxymethyl-Piperidine-1-Carboxylic Acid Benzyl Ester
1-benzyloxycarbonyl-4-hydroxymethylpiperidine
1-cbz-4-hydroxymethyl-piperidine
1-(Benzyloxycarbonyl)-4-piperidinemethanol
AS-18688
4-hydroxymethylpiperidine-1-carboxylic acid benzyl ester
n-benzyloxycarbonyl-4-hydroxymethylpiperidine
4-Hydroxymethyl-piperidine-l-carboxylic acid benzyl ester
z-isonicot(h6)-ol
benzyl 4-(hydroxymethyl)piperidine-1-carboxylate
benzyl 4-(hydroxymethyl)tetrahydro-1(2h)-pyridinecarboxylate
PB23274
N-benzyloxycarbonylpiperidine-4-methanol
benzyl4-(hydroxymethyl)piperidine-1-carboxylate
benzyl 4-(hydroxymethyl)-1-piperidinecarboxylate
MFCD02094490
CS-W002888
1-n-cbz-4-hydroxymethylpiperidine
AKOS009158309
FT-0622804
N-(Benzyloxycarbonyl)-4-(Hydroxymethyl)piperidine
LINIORCIRVAZSM-UHFFFAOYSA-N
1-cbz-4-hydroxy methyl piperidine
1-Piperidinecarboxylic acid, 4-(hydroxymethyl)-, phenylmethyl ester
N-Benzyloxycarbonyl-4-(hydroxymethyl)piperidine
SCHEMBL458805
EN300-189852
1-(benzyloxycarbonyl)-4-(hydroxymethyl)piperidine
Z635047520
phenylmethyl 4-(hydroxymethyl)-1-piperidine carboxylate

MDL Number

MFCD02094490

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Benzyl 4-(hydroxymethyl)-1-piperidinecarboxylate (CAS: 122860-33-7)?

Benzyl 4-(hydroxymethyl)-1-piperidinecarboxylate is a solid with a crystalline form. Its molecular weight is approximately 246.27 g/mol. The compound has a low solubility in water but is soluble in common organic solvents. It is reactive towards nucleophiles, showing moderate reactivity in organic synthesis. The compound has a pKa of about 13.5.

How is Benzyl 4-(hydroxymethyl)-1-piperidinecarboxylate (CAS: 122860-33-7) typically synthesized?

Benzyl 4-(hydroxymethyl)-1-piperidinecarboxylate is typically synthesized via the reaction of benzyl 4-formyl-1-piperidinecarboxylate with sodium hydroxide in ethanol. The reaction is carried out under mild conditions, resulting in a high yield. The reaction is selective and produces pure product with excellent yield.

What industries use Benzyl 4-(hydroxymethyl)-1-piperidinecarboxylate (CAS: 122860-33-7)?

Benzyl 4-(hydroxymethyl)-1-piperidinecarboxylate finds applications in the pharmaceutical industry for the synthesis of various drugs. It is also used in the polymer industry as a monomer for the development of new polymers. Additionally, it has potential uses in the sensor and semiconductor industries due to its chemical properties.

What precautions should be taken when handling Benzyl 4-(hydroxymethyl)-1-piperidinecarboxylate (CAS: 122860-33-7)?

When handling Benzyl 4-(hydroxymethyl)-1-piperidinecarboxylate, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be used. The compound should be handled in a fume hood to avoid inhalation. Spills should be cleaned up carefully using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Material Safety Data Sheet (MSDS) for specific safety guidelines.