1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone | CAS No. 1215994-75-4
1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone
Basic Information
CAS Number
1215994-75-4
Molecular Formula
C9H7BrF2O2
Molecular Weight
265.05 g/mol
AD
Chemical Classification
Basic Physical Properties
Boiling Point
292.4±40.0 °C(Predicted)
Density
1.537±0.06 g/cm3(Predicted)
Synonyms & References
English
- 1-[5-bromo-2-(difluoromethoxy)phenyl]ethan-1-one
- Ethanone, 1-[5-bromo-2-(difluoromethoxy)phenyl]-
- 5'-Bromo-2'-difluoromethoxyacetophenone
- 1-5-bromo-2-(difluoromethoxy)phenylethan-1-one
MDL Number
MFCD13188449
Customs Code
2914500090
FAQ
What are the physical and chemical properties of 1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone (CAS: 1215994-75-4)?
1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone (CAS: 1215994-75-4) is a crystalline solid with a molecular weight of approximately 313.03 g/mol. It is slightly soluble in water and more soluble in organic solvents like dichloromethane and ethanol. The compound shows moderate reactivity, especially towards nucleophiles and reducing agents. It exhibits good stability under normal conditions but is sensitive to strong bases and reducing agents.
How is 1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone (CAS: 1215994-75-4) typically synthesized?
1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone (CAS: 1215994-75-4) is usually synthesized by reacting 2-(difluoromethoxy)benzaldehyde with bromoacetyl chloride in the presence of a base such as sodium hydride. This method ensures high selectivity and yield. The reaction conditions include a dry, anhydrous solvent like dichloromethane and is typically carried out at room temperature.
What industries use 1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone (CAS: 1215994-75-4)?
1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone (CAS: 1215994-75-4) is primarily used in pharmaceutical research due to its functional groups that can be used for medicinal chemistry and drug synthesis. It also finds applications in the synthesis of organic intermediates for polymer chemistry, where its bromine and fluorine functionalities can be further modified. Additionally, it can be used in the development of new sensor materials and in the preparation of certain semiconducting compounds.
What precautions should be taken when handling 1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone (CAS: 1215994-75-4)?
When handling 1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone (CAS: 1215994-75-4), it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a well-ventilated area, preferably in a fume hood, to avoid exposure to air. Spills should be treated immediately with water and collected for proper disposal. Always refer to the Safety Data Sheet (SDS) for detailed precautions and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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