1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone(CAS: 1215994-75-4)

1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone (CAS: 1215994-75-4) is a crystalline solid with a molecular weight of approximately 313.03 g/mol. It is slightly soluble in water and more soluble in organic solvents like dichloromethane and ethanol. The compound shows moderate reactivity, especially towards nucleophiles and reducing agents. It exhibits good stability under normal conditions but is sensitive to strong bases and reducing agents.

1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone (CAS: 1215994-75-4) is usually synthesized by reacting 2-(difluoromethoxy)benzaldehyde with bromoacetyl chloride in the presence of a base such as sodium hydride. This method ensures high selectivity and yield. The reaction conditions include a dry, anhydrous solvent like dichloromethane and is typically carried out at room temperature.

1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone (CAS: 1215994-75-4) is primarily used in pharmaceutical research due to its functional groups that can be used for medicinal chemistry and drug synthesis. It also finds applications in the synthesis of organic intermediates for polymer chemistry, where its bromine and fluorine functionalities can be further modified. Additionally, it can be used in the development of new sensor materials and in the preparation of certain semiconducting compounds.

When handling 1-[5-Bromo-2-(difluoromethoxy)phenyl]ethanone (CAS: 1215994-75-4), it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a well-ventilated area, preferably in a fume hood, to avoid exposure to air. Spills should be treated immediately with water and collected for proper disposal. Always refer to the Safety Data Sheet (SDS) for detailed precautions and emergency procedures.