3-[(3R,4R)-3,4-Dimethyl-4-piperidinyl]phenol

Basic Information

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CAS Number

119193-19-0

Molecular Formula

C13H19NO

Molecular Weight

205.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

181.0 to 185.0 deg-C

Boiling Point

335.5°Cat760mmHg

Density

1.008

Flash Point

115.7°C

Refractive Index

1.521

SMILES

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C[C@H]1CNCC[C@@]1(C)c2cccc(c2)O

InChI

InChI=1S/C13H19NO/c1-10-9-14-7-6-13(10,2)11-4-3-5-12(15)8-11/h3-5,8,10,14-15H,6-7,9H2,1-2H3/t10-,13+/m0/s1

InChIKey

HXZDAOSDNCHKFE-GXFFZTMASA-N

LogP

2.2793000000000005

Topological Polar Surface Area

32.26 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

219

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE
3-(3,4-diMethylpiperidin-4-yl)phenol
3-[(3R,4R)-3,4-Dimethylpiperidin-4-yl]phenol
(3R,4R)-3-(3,4-Dimethyl-4-piperidinyl)phenol
Phenol,3-[(3R,4R)-3,4-dimethyl-4-piperidinyl]-
3-((3R,4R)-3,4-DIMETHYLPIPERDIN-4-YL)PHENOL
(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine
Alvimopan Intermediate 1
(3R,4R)-3-(3,4-diMethyl-4-piperidiny) phenol
3-((3R,4R)-3,4-diMethylpiperidin-4-yl)phenol
3-[(3R,4R)-3,4-DiMethyl-4-piperidinyl]phenol
(3R-cis)-3-(3,4-diMethyl-4- piperidinyl)phenol
(+)-(3R,4R)-DiMethyl-4-(3-hydroxyphenyl)piperidine
(+)-4(R)-(3-hydroxyphenyl)-3(R),4-diMethyl-1-piperidine
PHENOL, 3-[(3R,4R)-3,4-DIMETHYL-4-PIPERIDINYL]-
3-[(3R,4R)-3,4-dimethyl-4-piperidyl]phenol
KSC511C2F
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

MDL Number

MFCD06659960

Customs Code

2932999099

FAQ

What are the physical and chemical properties of 3-[(3R,4R)-3,4-Dimethyl-4-piperidinyl]phenol (CAS: 119193-19-0)?

3-[(3R,4R)-3,4-Dimethyl-4-piperidinyl]phenol is a white crystalline solid with a molecular weight of approximately 268.37 g/mol. It has low water solubility and is soluble in organic solvents such as ethanol and acetone. This compound exhibits moderate reactivity, particularly towards acidic or basic conditions, and shows stability under normal storage conditions.

How is 3-[(3R,4R)-3,4-Dimethyl-4-piperidinyl]phenol (CAS: 119193-19-0) typically synthesized?

3-[(3R,4R)-3,4-Dimethyl-4-piperidinyl]phenol is typically synthesized through the condensation of 4-(3,4-dimethylpiperidin-1-yl)benzaldehyde with phenol in the presence of a base such as sodium hydroxide. The reaction involves the formation of a condensation product followed by a reduction step to convert the aldehyde to a phenol.

What industries use 3-[(3R,4R)-3,4-Dimethyl-4-piperidinyl]phenol (CAS: 119193-19-0)?

3-[(3R,4R)-3,4-Dimethyl-4-piperidinyl]phenol is primarily used in the pharmaceutical industry for its biological activity, particularly as a precursor in the synthesis of bioactive compounds. It is also utilized in the production of certain polymers and as a stabilizer in chemical sensors and semiconductors.

What precautions should be taken when handling 3-[(3R,4R)-3,4-Dimethyl-4-piperidinyl]phenol (CAS: 119193-19-0)?

When handling 3-[(3R,4R)-3,4-Dimethyl-4-piperidinyl]phenol, appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat should be worn. The compound should be handled in a well-ventilated area or under a fume hood. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. An SDS (Safety Data Sheet) should be consulted for detailed handling and storage instructions.