Azithromycin hydrate

Basic Information

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CAS Number

117772-70-0

Molecular Formula

C38H76N2O14

Molecular Weight

749 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

129-135°C

Boiling Point

822.1°C at 760 mmHg

Flash Point

>110°(230°F)

Solubility

Soluble in DMSO at 20mg/ml. Also soluble in chloroform or ethylene chloride

Refractive Index

-47 ° (C=2, EtOH)

Specific Rotation

-44.0° - -49.0° (c=1, EtOH)

SMILES

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CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O.O.O

InChI

InChI=1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3

InChIKey

MQTOSJVFKKJCRP-UHFFFAOYSA-N

LogP

1.9007000000000054

Topological Polar Surface Area

180.07999999999998 Å²

Hydrogen Bond Donor/Acceptor

5 / 14

Complexity

1150

Safety Information

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Hazard Statement

H317 May cause an allergic skin reaction
Sensitization, Skin

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Sensitization, respiratory

Sensitiveness

Air Sensitive

Synonyms & References

English

Azithromycin dihydrate 100 microg/mL in Acetonitrile
AZITHROMYCIN [MART.]
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one dihydrate
Acitrocin
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one dihydrate
AZITHROMYCIN (MART.)
9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A dihydrate
AZITHROMYCIN DIHYDRATE [WHO-DD]
1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-?-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-?-D-xylo-hexopyranosyl]oxy]-, dihydrate, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
UNII-5FD1131I7S
Azitroxil
Misultina
HY-17506A
Azithromycin dihydrate; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-?-l-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-?-d-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one dihydrate
AZITHROMYCIN DIHYDRATE (EP MONOGRAPH)
AZITHROMYCIN DIHYDRATE (USP MONOGRAPH)
Q27116139
Azithromycin, Pharmaceutical Secondary Standard; Certified Reference Material
AZITHROMYCIN DIHYDRATE
Vinzam
AKOS015896370
1-Oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-, dihydrate, (2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,14R*))-
Ribotrex
Azitromax
AZITHROMYCIN DIHYDRATE [ORANGE BOOK]
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside dihydrate
AZITHROMYCIN DIHYDRATE [USP MONOGRAPH]
Dihydrate, Azithromycin
Azidromic
DTXCID201351422
Zenstavion

MDL Number

MFCD00873574

Customs Code

29419000

FAQ

What are the physical and chemical properties of Azithromycin hydrate (CAS: 117772-70-0)?

Azithromycin hydrate is an amorphous form of azithromycin with a molecular weight of approximately 918.97 g/mol. It is poorly soluble in water but soluble in organic solvents. The compound is relatively stable under normal conditions but may undergo degradation upon exposure to heat or light. It is not highly reactive but can undergo hydrolysis under acidic conditions.

How is Azithromycin hydrate (CAS: 117772-70-0) typically synthesized?

Azithromycin hydrate is synthesized through a multi-step process involving a key intermediate, 15-deoxy-15-methylerythromycin A. The synthesis typically requires the use of appropriate catalysts and solvents, with high selectivity and yield. Common methods include chemical derivatization and enzymatic modifications followed by purification steps.

What industries use Azithromycin hydrate (CAS: 117772-70-0)?

Azithromycin hydrate is primarily used in the pharmaceutical industry for the treatment of various bacterial infections. It is also used in veterinary medicine for similar applications. The compound has limited use in other industries such as polymers or semiconductors due to its specific pharmaceutical properties.

What precautions should be taken when handling Azithromycin hydrate (CAS: 117772-70-0)?

When handling Azithromycin hydrate, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety guidelines.