Azithromycin hydrate(CAS: 117772-70-0)

Azithromycin hydrate is an amorphous form of azithromycin with a molecular weight of approximately 918.97 g/mol. It is poorly soluble in water but soluble in organic solvents. The compound is relatively stable under normal conditions but may undergo degradation upon exposure to heat or light. It is not highly reactive but can undergo hydrolysis under acidic conditions.

Azithromycin hydrate is synthesized through a multi-step process involving a key intermediate, 15-deoxy-15-methylerythromycin A. The synthesis typically requires the use of appropriate catalysts and solvents, with high selectivity and yield. Common methods include chemical derivatization and enzymatic modifications followed by purification steps.

Azithromycin hydrate is primarily used in the pharmaceutical industry for the treatment of various bacterial infections. It is also used in veterinary medicine for similar applications. The compound has limited use in other industries such as polymers or semiconductors due to its specific pharmaceutical properties.

When handling Azithromycin hydrate, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety guidelines.