(1R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol

Basic Information

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CAS Number

114446-57-0

Molecular Formula

C8H7Cl3O

Molecular Weight

225.5 g/mol

Chemical Classification

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

46-47 ºC

SMILES

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Clc1cc(Cl)ccc1[C@@H](O)CCl

InChI

InChI=1S/C8H7Cl3O/c9-4-8(12)6-2-1-5(10)3-7(6)11/h1-3,8,12H,4H2/t8-/m0/s1

InChIKey

XHEPANNURIQWRM-QMMMGPOBSA-N

LogP

3.265600000000001

Topological Polar Surface Area

20.23 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

142

Synonyms & References

English

(R)-2-chloro-1-(2,4-dichlorophenyl)ethanol
(R)-2-chloro-1-(2,4-dichlorophenyl)ethan-1-ol
(1R)-2-chloro-1-(2,4-dichlorophenyl)ethanol
(1R)-2-chloro-1-(2,4-dichlorophenyl)ethan-1-ol
Benzenemethanol, 2,4-dichloro-alpha-(chloromethyl)-, (alphaR)-
NE36400
WT81677
C3424
(r)-2,2',4'-trichloro-1-phenylethan-1-ol
(R)-2-Chloro-(2',4'-dichlorophenyl)-1-ethanol
(R)-alpha-(Chloromethyl)-2,4-dichlorobenzyl alcohol

MDL Number

MFCD09863567

FAQ

What are the physical and chemical properties of (1R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol (CAS: 114446-57-0)?

(1R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol is a colorless to light yellow crystalline solid with a molecular weight of approximately 287.04 g/mol. It has a low water solubility but is more soluble in organic solvents like ethanol and acetone. This compound is known for its reactivity in nucleophilic substitution reactions and its ability to form stable complexes with various metal ions.

How is (1R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol (CAS: 114446-57-0) typically synthesized?

(1R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol is often synthesized through a multistep process involving the reaction of 2,4-dichlorophenyl bromide with sodium ethoxide in ethanol, followed by chlorination of the resulting intermediate. This method provides good yield and selectivity, though careful control of reaction conditions is essential to achieve the desired stereochemistry.

What industries use (1R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol (CAS: 114446-57-0)?

(1R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol is primarily used in the pharmaceutical industry, where it serves as a key intermediate in the synthesis of various drugs. It also finds applications in the sensor and semiconductor industries due to its specific chemical properties, making it a versatile molecule in modern chemistry.

What precautions should be taken when handling (1R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol (CAS: 114446-57-0)?

When handling (1R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood. Spills should be cleaned up using appropriate absorbents, and the area should be thoroughly ventilated. Always refer to the safety data sheet (SDS) for detailed information on handling and storage procedures.