How is (1R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol (CAS: 114446-57-0) typically synthesized?

(1R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol is often synthesized through a multistep process involving the reaction of 2,4-dichlorophenyl bromide with sodium ethoxide in ethanol, followed by chlorination of the resulting intermediate. This method provides good yield and selectivity, though careful control of reaction conditions is essential to achieve the desired stereochemistry.