2,6-Dichloro-5-fluoronicotinamide

Basic Information

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CAS Number

113237-20-0

Molecular Formula

C6H3Cl2FN2O

Molecular Weight

209.01 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

160-162

SMILES

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NC(=O)c1cc(F)c(nc1Cl)Cl

InChI

InChI=1S/C6H3Cl2FN2O/c7-4-2(6(10)12)1-3(9)5(8)11-4/h1H,(H2,10,12)

InChIKey

ZVYNUGSPFZCYEV-UHFFFAOYSA-N

LogP

1.6264

Topological Polar Surface Area

55.980000000000004 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

192

Safety Information

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Hazard Statement

Synonyms & References

English

2,6-Dichloro-5-fluoronicotinamide
2,6-dichloro-5-fluoropyridine-3-carboxamide
3-PyridinecarboxaMide, 2,6-dichloro-5-fluoro-
2,6-Dichloro-5-fluoropyridine-3-carboxamide, 3-Carbamoyl-2,6-dichloro-5-fluoropyridine
C6H3Cl2FN2O
ZVYNUGSPFZCYEV-UHFFFAOYSA-N
2,6-dichloro-5-fluoro-nicotinamide
PC6948
SBB055539
FCH1320898
SY056741
AB0001334
3-Carbamoyl-2,6-dichloro-5-fluoro
2,6-dichloro-5-fluoro-pyridine-3-carboxamide

MDL Number

MFCD01571365

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2,6-Dichloro-5-fluoronicotinamide (CAS: 113237-20-0)?

2,6-Dichloro-5-fluoronicotinamide is a white crystalline solid with a molecular weight of 243.01 g/mol. It has a solubility of 10.8 g/L in water at 25°C. The compound is moderately reactive and should be handled with care. It is slightly soluble in common organic solvents such as ethanol and acetone.

How is 2,6-Dichloro-5-fluoronicotinamide (CAS: 113237-20-0) typically synthesized?

2,6-Dichloro-5-fluoronicotinamide can be synthesized via a multi-step process involving the reaction of 3-chloro-5-fluoronicotinonitrile with hydrochloric acid. Common catalysts include phosphorus pentoxide or pyridine. The yield is typically around 70-80%, and the reaction is selective towards the desired product.

What industries use 2,6-Dichloro-5-fluoronicotinamide (CAS: 113237-20-0)?

2,6-Dichloro-5-fluoronicotinamide is primarily used in the pharmaceutical industry as an intermediate in the synthesis of antiviral drugs. It is also used in the field of materials science for the development of new sensor technologies and as a precursor in the production of advanced polymers.

What precautions should be taken when handling 2,6-Dichloro-5-fluoronicotinamide (CAS: 113237-20-0)?

When handling 2,6-Dichloro-5-fluoronicotinamide, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of accidental spillage, the area should be cleaned immediately using appropriate spill kits, and the material safety data sheet (MSDS) should be consulted for detailed instructions.