2,6-Dichloro-5-fluoronicotinamide(CAS: 113237-20-0)

2,6-Dichloro-5-fluoronicotinamide is a white crystalline solid with a molecular weight of 243.01 g/mol. It has a solubility of 10.8 g/L in water at 25°C. The compound is moderately reactive and should be handled with care. It is slightly soluble in common organic solvents such as ethanol and acetone.

2,6-Dichloro-5-fluoronicotinamide can be synthesized via a multi-step process involving the reaction of 3-chloro-5-fluoronicotinonitrile with hydrochloric acid. Common catalysts include phosphorus pentoxide or pyridine. The yield is typically around 70-80%, and the reaction is selective towards the desired product.

2,6-Dichloro-5-fluoronicotinamide is primarily used in the pharmaceutical industry as an intermediate in the synthesis of antiviral drugs. It is also used in the field of materials science for the development of new sensor technologies and as a precursor in the production of advanced polymers.

When handling 2,6-Dichloro-5-fluoronicotinamide, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of accidental spillage, the area should be cleaned immediately using appropriate spill kits, and the material safety data sheet (MSDS) should be consulted for detailed instructions.