DMT-2'O-Methyl-rU Phosphoramidite

Basic Information

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CAS Number

110764-79-9

Molecular Formula

C40H49N4O9P

Molecular Weight

17.03 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Insecticides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

InChI

InChI=1S/H3N/h1H3

InChIKey

QGZKDVFQNNGYKY-UHFFFAOYSA-N

LogP

0.16199999999999998

Topological Polar Surface Area

35.0 Å²

Hydrogen Bond Donor/Acceptor

3 / 1

Complexity

1240

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

C71367
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl diisopropylphosphoramidite)
(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
Dmt-2'o-methyl-ru amidite
DTXSID30447505
3-[({[(2R,3R,4R,5R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy}[bis(propan-2-yl)amino]phosphanyl)oxy]propanenitrile
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-methyluridine
5/'-O-(4,4-Dimethoxytrityl)-2/'-O-methyluridine-3/'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
DMT-2'-O-methyl-rU Phosphoramidite
CS-0154033
DMT-2'O-Methyl-rU Phosphoramidite
5'-O-DMT-2'-OMe-Uridine-CE Phosphoramidite
MFCD00792626
110764-79-9
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
AKOS016011613
J-700063
DMT-2'O-Methyl-rU Phosphoramidite, configured for MerMade
HY-W101391
AS-74548
DMT-2'O-Methyl-rU Phosphoramidite, configured for ABI
AC-32379
SCHEMBL1539684
DMT-2'O-Methyl-rU Phosphoramidite, configured for ??KTA(R) and OligoPilot(R)
BP-28833
5'-O-(4,4-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
5'-O-DMT-2'-O-Me-rU-3'-CEDPA
5'-O-DMT-2'-O-METHYLURIDINE 3'-CE PHOSPHORAMIDITE
Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)
5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-uridine 3'-[(2-cyanoethyl) (N,N-diisopropyl)phosphoramidite]

MDL Number

MFCD00792626

FAQ

What are the physical and chemical properties of DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9)?

DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9) is a white to off-white solid with a molecular weight of approximately 425.2 g/mol. It has a solubility of up to 10 mg/mL in water and is relatively stable under normal conditions. It is highly reactive, especially in the presence of碱性条件下的反应性。

How is DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9) typically synthesized?

DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9) is typically synthesized through the methylation of 2'-O-methyl-uridine followed by phosphoramidite formation. This process involves the use of methylating agents like methyl triflate and a catalyst such as 4-(dimethylamino)pyridine (DMAP). The yield is usually high, and the product is isolated by purification techniques like column chromatography.

What industries use DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9)?

DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9) is primarily used in the pharmaceutical industry for the synthesis of nucleoside analogs and pharmaceuticals. It also finds applications in polymer chemistry for the development of nucleic acid-based materials and in sensor technology for detecting nucleic acids and other biomolecules.

What precautions should be taken when handling DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9)?

When handling DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9), it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up immediately using absorbent materials and followed by thorough decontamination. Always refer to the safety data sheet (SDS) for specific handling and disposal instructions.