Compound Q&A
How is DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9) typically synthesized?
Answer
DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9) is typically synthesized through the methylation of 2'-O-methyl-uridine followed by phosphoramidite formation. This process involves the use of methylating agents like methyl triflate and a catalyst such as 4-(dimethylamino)pyridine (DMAP). The yield is usually high, and the product is isolated by purification techniques like column chromatography.
About
CAS No
110764-79-9
English Name
DMT-2'O-Methyl-rU Phosphoramidite
Molecular Formula
C40H49N4O9P
Molecular Weight
17.03 g/mol
SMILES
CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
InChIKey
QGZKDVFQNNGYKY-UHFFFAOYSA-N
Last Updated: 2025-10-13 19:39
