DMT-2'O-Methyl-rU Phosphoramidite(CAS: 110764-79-9)

DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9) is a white to off-white solid with a molecular weight of approximately 425.2 g/mol. It has a solubility of up to 10 mg/mL in water and is relatively stable under normal conditions. It is highly reactive, especially in the presence of碱性条件下的反应性。

DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9) is typically synthesized through the methylation of 2'-O-methyl-uridine followed by phosphoramidite formation. This process involves the use of methylating agents like methyl triflate and a catalyst such as 4-(dimethylamino)pyridine (DMAP). The yield is usually high, and the product is isolated by purification techniques like column chromatography.

DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9) is primarily used in the pharmaceutical industry for the synthesis of nucleoside analogs and pharmaceuticals. It also finds applications in polymer chemistry for the development of nucleic acid-based materials and in sensor technology for detecting nucleic acids and other biomolecules.

When handling DMT-2'O-Methyl-rU Phosphoramidite (CAS: 110764-79-9), it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up immediately using absorbent materials and followed by thorough decontamination. Always refer to the safety data sheet (SDS) for specific handling and disposal instructions.