Angiotensinogen (1-14) (rat)

Basic Information

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CAS Number

110200-37-8

Molecular Formula

C89H123N21O21

Molecular Weight

1823.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CCC(C)C(C(=O)NC(CC1=CNC=N1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CNC=N4)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(CO)C(=O)O)NC(=O)C(CC7=CC=C(C=C7)O)NC(=O)C(C(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)O)N

InChI

InChI=1S/C89H123N21O21/c1-9-50(8)74(109-83(125)67(38-54-23-29-59(114)30-24-54)105-85(127)73(49(6)7)108-76(118)61(17-13-31-95-89(91)92)98-75(117)60(90)41-72(115)116)86(128)106-69(40-56-43-94-46-97-56)87(129)110-32-14-18-71(110)84(126)104-66(35-51-15-11-10-12-16-51)80(122)103-68(39-55-42-93-45-96-55)82(124)100-62(33-47(2)3)77(119)99-63(34-48(4)5)78(120)101-64(36-52-19-25-57(112)26-20-52)79(121)102-65(37-53-21-27-58(113)28-22-53)81(123)107-70(44-111)88(130)131/h10-12,15-16,19-30,42-43,45-50,60-71,73-74,111-114H,9,13-14,17-18,31-41,44,90H2,1-8H3,(H,93,96)(H,94,97)(H,98,117)(H,99,119)(H,100,124)(H,101,120)(H,102,121)(H,103,122)(H,104,126)(H,105,127)(H,106,128)(H,107,123)(H,108,118)(H,109,125)(H,115,116)(H,130,131)(H4,91,92,95)/t50-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,73-,74-/m0/s1

InChIKey

FFCYBSGRCYFCNM-YXRWNMRVSA-N

LogP

5.27060

Topological Polar Surface Area

670.31 Å²

Hydrogen Bond Donor/Acceptor

26 / 42

Complexity

3760

Synonyms & References

English

ANGIOTENSINOGEN (1-14) (RAT)
110200-37-8
Angiotensinogen(1-14)(rat)
L-Serine, L-a-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-tyrosyl-L-tyrosyl-
Angiotensinogen(1-14),Rat
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-TYR-TYR-SER
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Tyr-Tyr-Ser-OH
L-Serine, L-a-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylala...
L-Serine, L-a-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucy
Renin Substrate Tetradecapeptide, rat
TETRADECAPEPTIDE
Tetradecapeptide Renin Substrate (rat)
Angiotensi
PREANGIOTENSINOGEN (1-14)
PREANGIOTENSINOGEN (1-14) (RAT)
Tetradecapeptide Renin Substrate (rat),Preangiotensinogen (1-14) (rat),Angiotensinogen (1-14) (rat)
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-TYR-TYR-SER: DRVYIHPFHLLYYS
L-alpha-Aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-tyrosyl-L-tyrosyl-L-serine

MDL Number

MFCD00167485

FAQ

What are the physical and chemical properties of Angiotensinogen (1-14) (rat) (CAS: 110200-37-8)?

Angiotensinogen (1-14) (rat) is a peptide with a molecular weight of approximately 1654.4 Da. It is a white to off-white crystalline powder with good solubility in water. Physically, it is stable at room temperature but may degrade under extreme pH conditions. Chemically, it is susceptible to proteolytic degradation and is reactive with various reagents.

How is Angiotensinogen (1-14) (rat) (CAS: 110200-37-8) typically synthesized?

Angiotensinogen (1-14) (rat) is typically synthesized via solid-phase peptide synthesis. The process involves stepwise coupling of protected amino acids to a solid support, followed by cleavage from the support and purification. Commonly used protecting groups include Boc (t-butyloxycarbonyl) and Fmoc (fluorenylmethoxycarbonyl) with coupling reagents like HATU or PyBOP. The selectivity and yield are high due to the controlled environment of the synthesis reactor.

What industries use Angiotensinogen (1-14) (rat) (CAS: 110200-37-8)?

Angiotensinogen (1-14) (rat) is primarily used in the pharmaceutical industry for studying angiotensinogen-related pathways and for the development of hypertension drugs. It is also used in research applications involving signal transduction and cell biology. Additionally, it can be employed in biotechnology for protein engineering and in diagnostics for assay development.

What precautions should be taken when handling Angiotensinogen (1-14) (rat) (CAS: 110200-37-8)?

Precautions when handling Angiotensinogen (1-14) (rat) include wearing personal protective equipment (PPE) such as gloves and protective eyewear. Work should be conducted in a fume hood to avoid inhalation of dust or vapors. Spills should be cleaned up with caution using appropriate absorbents. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.