Amyloid beta-Protein (1-28)

Basic Information

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CAS Number

109770-29-8

Molecular Formula

C145H209N41O46

Molecular Weight

3262.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C)CC(C(=O)NC(C(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)N)NC(=O)C(CC3=CNC=N3)NC(=O)C(CC4=CNC=N4)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CC6=CNC=N6)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC(=O)O)N

InChI

InChI=1S/C145H209N41O46/c1-71(2)49-93(138(225)186-118(74(7)8)142(229)181-97(52-79-29-18-13-19-30-79)132(219)175-95(50-77-25-14-11-15-26-77)129(216)163-76(10)120(207)167-90(40-44-111(196)197)127(214)179-103(60-115(204)205)139(226)184-116(72(3)4)141(228)158-65-109(193)165-105(67-188)140(227)178-101(58-107(150)191)136(223)172-92(144(231)232)32-21-23-47-147)173-123(210)86(31-20-22-46-146)168-125(212)88(38-42-106(149)190)170-133(220)98(54-81-61-153-68-159-81)177-135(222)100(56-83-63-155-70-161-83)182-143(230)117(73(5)6)185-128(215)91(41-45-112(198)199)171-130(217)94(53-80-34-36-84(189)37-35-80)164-108(192)64-157-122(209)104(66-187)183-137(224)102(59-114(202)203)180-134(221)99(55-82-62-154-69-160-82)176-124(211)87(33-24-48-156-145(151)152)169-131(218)96(51-78-27-16-12-17-28-78)174-126(213)89(39-43-110(194)195)166-119(206)75(9)162-121(208)85(148)57-113(200)201/h11-19,25-30,34-37,61-63,68-76,85-105,116-118,187-189H,20-24,31-33,38-60,64-67,146-148H2,1-10H3,(H2,149,190)(H2,150,191)(H,153,159)(H,154,160)(H,155,161)(H,157,209)(H,158,228)(H,162,208)(H,163,216)(H,164,192)(H,165,193)(H,166,206)(H,167,207)(H,168,212)(H,169,218)(H,170,220)(H,171,217)(H,172,223)(H,173,210)(H,174,213)(H,175,219)(H,176,211)(H,177,222)(H,178,227)(H,179,214)(H,180,221)(H,181,229)(H,182,230)(H,183,224)(H,184,226)(H,185,215)(H,186,225)(H,194,195)(H,196,197)(H,198,199)(H,200,201)(H,202,203)(H,204,205)(H,231,232)(H4,151,152,156)

InChIKey

CMKVKXQGLWBAFY-UHFFFAOYSA-N

LogP

-13.956330000000092

Topological Polar Surface Area

1419.6699999999994 Å²

Hydrogen Bond Donor/Acceptor

54 / 87

Complexity

7650

Synonyms & References

English

Amyloid beta-Protein (1-28)
109770-29-8
BETA-AMYLOID (1-28)
1-28-Glycopeptide(human clone 9-110 amyloid A4 peptide moiety) (9CI)
[beta]-Amyloid (1-28)
Amyloid β -Protein (1- 28)
DAEFRHDSGYEVHHQKLVFFAEDVGSNK
H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
Amyloid .beta.-Protein (1-28)
SP28
Fam-β-Amyloid
AMyloid b-Protein (1-28)
AMYLOID BETA-PROTEIN (1-28)
AMYLOID, BETA- (1-28), HUMAN
amyloid B-protein fragment 1-28
AMYLOID BETA-PROTEIN FRAGMENT 1-28
AMYLOID-BETA PROTEIN (1-28), HUMAN
β-Amyloid (1-28)

MDL Number

MFCD00133074

FAQ

What are the physical and chemical properties of Amyloid beta-Protein (1-28) (CAS: 109770-29-8)?

Amyloid beta-Protein (1-28) is a peptide with a molecular weight of approximately 3,261.28 g/mol. It appears as a white to off-white powder in its crystalline form. The protein is poorly soluble in water but more soluble in organic solvents like acetonitrile. It is relatively stable at room temperature and in aqueous solutions, exhibiting limited reactivity with common reagents.

How is Amyloid beta-Protein (1-28) (CAS: 109770-29-8) typically synthesized?

Amyloid beta-Protein (1-28) is typically synthesized using solid-phase peptide synthesis (SPPS). The process involves the stepwise addition of amino acids to a growing peptide chain on a solid support, followed by cleavage from the support and purification. Commonly used protecting groups include FMOC and Boc, with high yield and good purity after purification steps.

What industries use Amyloid beta-Protein (1-28) (CAS: 109770-29-8)?

Amyloid beta-Protein (1-28) is primarily used in the pharmaceutical industry for research into Alzheimer's disease and other neurodegenerative disorders. It is also utilized in the production of diagnostic tools, particularly in the development of amyloid beta-based biosensors. Additionally, it has potential applications in biomedical research and nanotechnology.

What precautions should be taken when handling Amyloid beta-Protein (1-28) (CAS: 109770-29-8)?

When handling Amyloid beta-Protein (1-28), it is crucial to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate methodologies, and an SDS (Safety Data Sheet) should be consulted for detailed handling and disposal procedures.