(2,6-Dichloro-4-pyridinyl)boronic acid

Basic Information

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CAS Number

1072951-54-2

Molecular Formula

C5H4BCl2NO2

Molecular Weight

191.81 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

396.8°C at 760 mmHg

SMILES

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OB(c1cc(Cl)nc(c1)Cl)O

InChI

InChI=1S/C5H4BCl2NO2/c7-4-1-3(6(10)11)2-5(8)9-4/h1-2,10-11H

InChIKey

JFUQZFQJFYZZGY-UHFFFAOYSA-N

LogP

0.06819999999999993

Topological Polar Surface Area

53.35000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

128

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(2,6-Dichloropyridin-4-yl)boronic acid
2,6-Dichloropyridine-4-boronic acid
2,6-Dichloropyridine-4-boronicacid
2,6-dichloropyridin-4-ylboronic acid
(2,6-dichloro-4-pyridyl)boronic acid
Boronic acid, B-(2,6-dichloro-4-pyridinyl)-
JFUQZFQJFYZZGY-UHFFFAOYSA-N
BCP21909
EBD215189
FCH869783
AB51429
AM86070
(2,6-dichloro-4-pyridinyl)boroni
(2,6-dichloro-4-pyridinyl)boronic acid
(2,6-dichloropyridin-4-yl)boronic acid

MDL Number

MFCD09751352

Customs Code

2933399090

FAQ

What are the physical and chemical properties of (2,6-Dichloro-4-pyridinyl)boronic acid (CAS: 1072951-54-2)?

(2,6-Dichloro-4-pyridinyl)boronic acid is a solid with a crystalline form. Its molecular weight is approximately 227.03 g/mol. It has a low water solubility and moderate solubility in organic solvents. The compound is moderately reactive with nucleophiles and shows good selectivity in boronate ester formation reactions.

How is (2,6-Dichloro-4-pyridinyl)boronic acid (CAS: 1072951-54-2) typically synthesized?

(2,6-Dichloro-4-pyridinyl)boronic acid is commonly synthesized via the reaction of 2,6-dichloropyridine with boron tribromide followed by treatment with a base. The reaction is catalyzed by a Lewis acid and proceeds with high selectivity, yielding a high purity product with a yield of about 75-80%.

What industries use (2,6-Dichloro-4-pyridinyl)boronic acid (CAS: 1072951-54-2)?

(2,6-Dichloro-4-pyridinyl)boronic acid finds applications in pharmaceuticals, where it is used as a precursor in the synthesis of drugs. It is also utilized in the polymer industry for the preparation of boronate esters, and in the sensor industry for its use in detecting specific chemical species. Additionally, it is used in semiconductor manufacturing for certain deposition processes.

What precautions should be taken when handling (2,6-Dichloro-4-pyridinyl)boronic acid (CAS: 1072951-54-2)?

When handling (2,6-Dichloro-4-pyridinyl)boronic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. In case of spill, immediately clean up with appropriate absorbent materials and dispose of in accordance with local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.