(2,6-Dichloro-4-pyridinyl)boronic acid(CAS: 1072951-54-2)

(2,6-Dichloro-4-pyridinyl)boronic acid is a solid with a crystalline form. Its molecular weight is approximately 227.03 g/mol. It has a low water solubility and moderate solubility in organic solvents. The compound is moderately reactive with nucleophiles and shows good selectivity in boronate ester formation reactions.

(2,6-Dichloro-4-pyridinyl)boronic acid is commonly synthesized via the reaction of 2,6-dichloropyridine with boron tribromide followed by treatment with a base. The reaction is catalyzed by a Lewis acid and proceeds with high selectivity, yielding a high purity product with a yield of about 75-80%.

(2,6-Dichloro-4-pyridinyl)boronic acid finds applications in pharmaceuticals, where it is used as a precursor in the synthesis of drugs. It is also utilized in the polymer industry for the preparation of boronate esters, and in the sensor industry for its use in detecting specific chemical species. Additionally, it is used in semiconductor manufacturing for certain deposition processes.

When handling (2,6-Dichloro-4-pyridinyl)boronic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. In case of spill, immediately clean up with appropriate absorbent materials and dispose of in accordance with local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.