Amorolfinehydrochloride

Basic Information

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CAS Number

106614-68-0

Molecular Formula

C21H36ClNO

Molecular Weight

354 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2CC(OC(C2)C)C.Cl

InChI

InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;

InChIKey

XZKWIPVTHGWDCF-KUZYQSSXSA-N

Complexity

336

Synonyms & References

English

(2R,6S)-rel-2,6-Dimethyl-4-(2-methyl-3-(4-(tert-pentyl)phenyl)propyl)morpholine hydrochloride
Bekiron
Amorolfine hydrochloride (JAN)
Amorolfine (as hydrochloride)
CCG-213057
78613-38-4 (HCl)
SCHEMBL36711
78613-38-4
(2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine hydrochloride
amorolfine hydrochloride
s1676
D01720
Amorolfine hydrochloride- Bio-X
Pekiron
AMOROLFINE HYDROCHLORIDE [MI]
AKOS015912323
Pekiron (TN)
Amorolfine hydrochloride [JAN]
CHEBI:59649
2,6-Dimethyl-4-(2-methyl-3-(4-(tert-pentyl)phenyl)propyl)morpholine hydrochloride
741YH7379H
Odenil
AMOROLFINE HYDROCHLORIDE [WHO-DD]
SW219285-1
AC-080
AMOROLFINE HYDROCHLORIDE [EP MONOGRAPH]
MLS006010200
Curanail
Amorolfine for system suitability
AS-13295
Loceryl

MDL Number

MFCD00903738

FAQ

What are the physical and chemical properties of Amorolfinehydrochloride (CAS: 106614-68-0)?

Amorolfinehydrochloride is a crystalline compound with a molecular weight of approximately 265.7 g/mol. It has a pKa of about 2.1 and is poorly soluble in water but soluble in organic solvents like methanol and ethanol. Amorolfinehydrochloride is less reactive than most carboxylic acids, showing limited reactivity in standard organic reactions. It is stable under normal storage conditions but may degrade under acidic or basic conditions.

How is Amorolfinehydrochloride (CAS: 106614-68-0) typically synthesized?

Amorolfinehydrochloride is typically synthesized by the reaction of amorolfine with hydrochloric acid. The process involves the condensation of 2,2-dimethyl-4-(5-(trifluoromethyl)-1H-indol-3-yl)-2-methylpropan-1-one with hydrochloric acid in an appropriate solvent at elevated temperature. The reaction is catalyzed by acidic conditions, and the yield is generally around 70-80%. The selectivity is high, with minimal formation of by-products.

What industries use Amorolfinehydrochloride (CAS: 106614-68-0)?

Amorolfinehydrochloride is primarily used in the pharmaceutical industry for the treatment of nail infections such as onychomycosis. It is also used in polymer applications, where its antifungal properties can be utilized in the formulation of antifungal coatings and paints. Other industries that may use it include hygiene products and medical devices.

What precautions should be taken when handling Amorolfinehydrochloride (CAS: 106614-68-0)?

When handling Amorolfinehydrochloride, wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Store it in a cool, dry place away from direct sunlight. Work in a well-ventilated area or fume hood to avoid inhalation of the compound. In case of spill, do not use a broom to clean up; instead, use absorbent material and dispose of it according to local regulations. Refer to the safety data sheet (SDS) for detailed information on handling and storage.