Compound Q&A
How is Amorolfinehydrochloride (CAS: 106614-68-0) typically synthesized?
Answer
Amorolfinehydrochloride is typically synthesized by the reaction of amorolfine with hydrochloric acid. The process involves the condensation of 2,2-dimethyl-4-(5-(trifluoromethyl)-1H-indol-3-yl)-2-methylpropan-1-one with hydrochloric acid in an appropriate solvent at elevated temperature. The reaction is catalyzed by acidic conditions, and the yield is generally around 70-80%. The selectivity is high, with minimal formation of by-products.
About
CAS No
106614-68-0
English Name
Amorolfinehydrochloride
Molecular Formula
C21H36ClNO
Molecular Weight
354 g/mol
SMILES
CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2CC(OC(C2)C)C.Cl
InChIKey
XZKWIPVTHGWDCF-KUZYQSSXSA-N
Last Updated: 2025-10-13 12:55
