(R)-2-(3,4-Difluorobenzyl)pyrrolidine-2-carboxylic acid hydrochloride | CAS No. 1049732-11-7
(R)-2-(3,4-Difluorobenzyl)pyrrolidine-2-carboxylic acid hydrochloride
Basic Information
CAS Number
1049732-11-7
Molecular Formula
C12H14ClF2NO2
Molecular Weight
277.7 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- (R)-2-(3,4-Difluorobenzyl)pyrrolidine-2-carboxylic acid hydrochloride
- (R)-alpha-(3,4-difluorobenzyl)-proline-HCl
- (2R)-2-[(3,4-difluorophenyl)methyl]pyrrolidine-2-carboxylic Acid Hydrochloride
- AC1MC5ZK
- AK120298
- KB-209725
- MolPort-003-794-530
- (R)-a-(3,4-Difluorobenzyl)proline·HCl
- (R)-Alpha-(3,4-difluoro-benzyl)-ProHCl
- 1049732-11-7
- AKOS015949877
- starbld0000458
- (2R)-2-[(3,4-difluorophenyl)methyl]pyrrolidine-2-carboxylic acid;hydrochloride
- MFCD06796789
- F86444
- DTXSID70375974
- (R)-alpha-(3,4-Difluoro-benzyl)-proline-HCl
MDL Number
MFCD06796789
Customs Code
2933990090
FAQ
What are the physical and chemical properties of (R)-2-(3,4-Difluorobenzyl)pyrrolidine-2-carboxylic acid hydrochloride (CAS: 1049732-11-7)?
This compound is a white crystalline solid with a molecular weight of 294.08 g/mol. It has a low solubility in water but is more soluble in organic solvents. It is moderately reactive towards bases and nucleophiles. Its melting point is around 200-210°C. The compound is chiral and exhibits good stability under normal conditions.
How is (R)-2-(3,4-Difluorobenzyl)pyrrolidine-2-carboxylic acid hydrochloride (CAS: 1049732-11-7) typically synthesized?
This compound can be synthesized via the condensation of (R)-2-(3,4-difluorobenzyl)pyrrolidine with acetic anhydride, followed by the addition of hydrochloric acid. The synthesis uses acetic anhydride as the condensing agent and hydrochloric acid for the final protonation step. The reaction yields a high purity product with high selectivity.
What industries use (R)-2-(3,4-Difluorobenzyl)pyrrolidine-2-carboxylic acid hydrochloride (CAS: 1049732-11-7)?
This compound is primarily used in the pharmaceutical industry for the development of drug candidates, particularly for central nervous system (CNS) applications. It is also used in the synthesis of certain polymers and as a precursor in sensor and semiconductor applications.
What precautions should be taken when handling (R)-2-(3,4-Difluorobenzyl)pyrrolidine-2-carboxylic acid hydrochloride (CAS: 1049732-11-7)?
When handling this compound, safety gloves and safety goggles should be worn. Work in a well-ventilated area or fume hood to avoid inhalation. Store the compound in a cool, dry place away from direct sunlight. In case of spill, avoid inhaling dust and use personal protective equipment. Refer to the Material Safety Data Sheet (MSDS) for further details on handling and storage.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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