5-Chloro-4-fluoro-2-nitroaniline

Basic Information

View in Editor

CAS Number

104222-34-6

Molecular Formula

C6H4ClFN2O2

Molecular Weight

190.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

140.0 to 144.0 deg-C

Boiling Point

336.1°Cat760mmHg

Flash Point

157.1°C

Refractive Index

1.617

SMILES

View in Editor

C1=C(C(=CC(=C1Cl)F)[N+](=O)[O-])N

InChI

InChI=1S/C6H4ClFN2O2/c7-3-1-5(9)6(10(11)12)2-4(3)8/h1-2H,9H2

InChIKey

VRJKEIWZSOHDOH-UHFFFAOYSA-N

LogP

3.07390

Complexity

187

Safety Information

View Safety Information

GHS Hazard Pictograms

H301

H311

H331

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H311 Toxic in contact with skin
Acute toxicity, dermal

H331 Toxic if inhaled
Acute toxicity, inhalation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

104222-34-6
MFCD00052698
A19794
AM61724
2-nitro-4-fluoro-5-chloroaniline
Benzenamine,5-chloro-4-fluoro-2-nitro-
5-chloro-4-fluoro-2-nitrobenzenamine
AKOS006220716
W-204527
AC-3726
EN300-220601
SCHEMBL1877078
C3141
SY057047
5-chloro-4-fluoro-2-nitro-phenylamine
FT-0620297
DTXSID00333729
Benzenamine, 5-chloro-4-fluoro-2-nitro-
5-Chloro-4-fluoro-2-nitroaniline
DS-11949
NS00015814
CS-W015869
3-Chloro-4-fluoro-6-nitroaniline
TIMTEC-BB SBB003647
BUTTPARK 45\03-11
BENZENAMINE,5-CHLORO-4-FLUORO-2-NITRO
3-chloro-4-fluoro-6-nitroaniline
5-chloro-4-fluoro-2-nitro-aniline
5-chloro-4-fluoro-2-nitrophenylamine
5-Chloro-4-fluoro-2-nitro-phenylamine
2-Amino-4-chloro-5-fluoronitrobenzene

MDL Number

MFCD00052698

Customs Code

2921420090

FAQ

What are the physical and chemical properties of 5-Chloro-4-fluoro-2-nitroaniline (CAS: 104222-34-6)?

5-Chloro-4-fluoro-2-nitroaniline (CAS: 104222-34-6) is a crystalline solid with a molecular weight of 188.01 g/mol. It has a melting point of 168-169°C. The compound is only slightly soluble in water but soluble in organic solvents like ethanol and acetone. It shows good reactivity towards nucleophiles and electrophiles, making it a versatile intermediate in organic synthesis.

How is 5-Chloro-4-fluoro-2-nitroaniline (CAS: 104222-34-6) typically synthesized?

5-Chloro-4-fluoro-2-nitroaniline (CAS: 104222-34-6) can be synthesized through the nitration of 4-chloro-2-fluoroaniline with nitric acid in the presence of sulfuric acid as a catalyst. The reaction yields 5-Chloro-4-fluoro-2-nitroaniline with high selectivity and moderate to good yield, typically around 70-80%.

What industries use 5-Chloro-4-fluoro-2-nitroaniline (CAS: 104222-34-6)?

5-Chloro-4-fluoro-2-nitroaniline (CAS: 104222-34-6) is used in various industries including pharmaceuticals, where it serves as a precursor for the synthesis of certain drugs. It is also used in the production of dyes and pigments, as a component in organic electronics, and in the development of new materials for sensors and semiconductors.

What precautions should be taken when handling 5-Chloro-4-fluoro-2-nitroaniline (CAS: 104222-34-6)?

5-Chloro-4-fluoro-2-nitroaniline (CAS: 104222-34-6) should be handled with caution due to its reactivity and potential for forming explosive compounds. Always perform operations in a well-ventilated fume hood and use appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. Store the compound in a cool, dry place away from sources of ignition and incompatible materials. Refer to the Material Safety Data Sheet (MSDS) for more detailed safety information.