Compound Q&A

How is 5-Chloro-4-fluoro-2-nitroaniline (CAS: 104222-34-6) typically synthesized?

Answer

5-Chloro-4-fluoro-2-nitroaniline
5-Chloro-4-fluoro-2-nitroaniline (CAS: 104222-34-6) can be synthesized through the nitration of 4-chloro-2-fluoroaniline with nitric acid in the presence of sulfuric acid as a catalyst. The reaction yields 5-Chloro-4-fluoro-2-nitroaniline with high selectivity and moderate to good yield, typically around 70-80%.

About

English Name 5-Chloro-4-fluoro-2-nitroaniline
Molecular Formula C6H4ClFN2O2
Molecular Weight 190.56 g/mol
SMILES C1=C(C(=CC(=C1Cl)F)[N+](=O)[O-])N
InChIKey VRJKEIWZSOHDOH-UHFFFAOYSA-N
Last Updated: 2025-10-22 12:37

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