Vapreotide | CAS No. 103222-11-3

Vapreotide

Basic Information

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CAS Number

103222-11-3

Molecular Formula

C57H70N12O9S2

Molecular Weight

1131.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C)C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=CC=C5)N)C(=O)NC(CC6=CNC7=CC=CC=C76)C(=O)N

InChI

InChI=1S/C57H70N12O9S2/c1-32(2)49-57(78)68-48(55(76)64-44(50(60)71)26-35-28-61-41-16-8-6-14-38(35)41)31-80-79-30-47(67-51(72)40(59)24-33-12-4-3-5-13-33)56(77)65-45(25-34-19-21-37(70)22-20-34)53(74)66-46(27-36-29-62-42-17-9-7-15-39(36)42)54(75)63-43(52(73)69-49)18-10-11-23-58/h3-9,12-17,19-22,28-29,32,40,43-49,61-62,70H,10-11,18,23-27,30-31,58-59H2,1-2H3,(H2,60,71)(H,63,75)(H,64,76)(H,65,77)(H,66,74)(H,67,72)(H,68,78)(H,69,73)/t40-,43+,44+,45+,46-,47+,48+,49+/m1/s1

InChIKey

SWXOGPJRIDTIRL-DOUNNPEJSA-N

LogP

2.011600000000011

Topological Polar Surface Area

350.63999999999993 Å²

Hydrogen Bond Donor/Acceptor

16 / 21

Complexity

2080

Synonyms & References

English

(4R,7S,10S,13S,16S,19R)-10-(4-aminobutyl)-N-[(2R)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Sanvar IR; Vapreotidum; RC 160; RC-160; RC160
(4R,7S,10S,13R,16S,19R)-13-((1H-Indol-3-yl)methyl)-N-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-19-((R)-2-amino-3-phenylpropanamido)-10-(4-aminobutyl)-16-(4-hydroxybenzyl)-7-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide
SCHEMBL6369050
NSC_71306
RC160;BMY 41606
CAS_71306
RC-160
BDBM82464
CCRIS 6495
F85455
RC 160
BCP21232
BMY 41606
D06281
RC-160 (Vapreotide)
103222-11-3
AKOS015896024
Vapreotide
Vapreotide (USAN/INN)
GTPL2054
FT-0652516
L-Tryptophanamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2?7)-disulfide, acetate (1:?);L-Tryptophanamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2?7)-disulfide, acetate (1:?)
L001100
Sanvar
RC-160(VAPREOTIDE)
Vapreotide Acetate
BMY-41606
D-PHE-CYS-TYR-D-TRP-LYS-VAL-CYS-TRP-NH2
FCYWKVCW-NH2
H-D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2

MDL Number

MFCD30489723

FAQ

What are the physical and chemical properties of Vapreotide (CAS: 103222-11-3)?

Vapreotide (CAS: 103222-11-3) is a cyclic octapeptide with a molecular weight of approximately 1089.3 Da. It is poorly soluble in water but soluble in organic solvents. Vapreotide is not highly reactive under normal conditions but can be sensitive to hydrolysis in aqueous solutions. It crystallizes in a form that is stable under typical laboratory conditions.

How is Vapreotide (CAS: 103222-11-3) typically synthesized?

Vapreotide (CAS: 103222-11-3) is typically synthesized via solid-phase peptide synthesis (SPPS). Commonly, the peptide is built using Fmoc chemistry with a protected amino acid resin. The synthesis involves stepwise coupling of protected amino acids, removal of the protecting groups, and final deprotection to yield the active peptide. The yield and purity are typically high, with efficient removal of by-products and side-products.

What industries use Vapreotide (CAS: 103222-11-3)?

Vapreotide (CAS: 103222-11-3) is primarily used in the pharmaceutical industry. It is approved for the treatment of acromegaly and certain neuroendocrine tumors. While it has applications in research and development, its main commercial use is in the pharmaceutical sector for therapeutic purposes.

What precautions should be taken when handling Vapreotide (CAS: 103222-11-3)?

When handling Vapreotide (CAS: 103222-11-3), it is important to use appropriate personal protective equipment (PPE) such as gloves and goggles. Storage should be in a cool, dry place away from light and humidity. Fume hoods should be used during synthesis or handling to minimize exposure. In case of a spill, it should be cleaned up according to the manufacturer's safety data sheet (SDS). Always refer to the SDS for detailed handling and disposal instructions.